Potential of long non‐coding RNAs in cancer patients: from biomarkers to therapeutic targets

S Chandra Gupta… - International journal of …, 2017 - Wiley Online Library
Because of high specificity and easy detection in the tissues, serum, plasma, urine and
saliva, interest in exploring the potential of long non‐coding RNAs (lncRNAs) in cancer …

Long non-coding RNAs are emerging targets of phytochemicals for cancer and other chronic diseases

S Mishra, SS Verma, V Rai, N Awasthee… - Cellular and Molecular …, 2019 - Springer
The long non-coding RNAs (lncRNAs) are the crucial regulators of human chronic diseases.
Therefore, approaches such as antisense oligonucleotides, RNAi technology, and small …

From junk to master regulators of invasion: lncRNA functions in migration, EMT and metastasis

S Dhamija, S Diederichs - International journal of cancer, 2016 - Wiley Online Library
Metastasis is a multistep process that involves the dissemination of cells from the primary
tumor and colonization of distant secondary organs. Epithelial cells at the invasive front of a …

Analysis of the androgen receptor–regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression

Y Zhang, S Pitchiaya, M Cieślik, YS Niknafs, JCY Tien… - Nature …, 2018 - nature.com
The androgen receptor (AR) plays a critical role in the development of the normal prostate
as well as prostate cancer. Using an integrative transcriptomic analysis of prostate cancer …

The bright side of dark matter: lncRNAs in cancer

JR Evans, FY Feng… - The Journal of clinical …, 2016 - Am Soc Clin Investig
The traditional view of genome organization has been upended in the last decade with the
discovery of vast amounts of non–protein-coding transcription. After initial concerns that this …

Interfering with long non-coding RNA MIR22HG processing inhibits glioblastoma progression through suppression of Wnt/β-catenin signalling

M Han, S Wang, S Fritah, X Wang, W Zhou, N Yang… - Brain, 2020 - academic.oup.com
Long non-coding RNAs play critical roles in tumour progression. Through analysis of
publicly available genomic datasets, we found that MIR22HG, the host gene of microRNAs …

Long noncoding RNAs in cancer: from function to translation

A Sahu, U Singhal, AM Chinnaiyan - Trends in cancer, 2015 - cell.com
While our understanding of the molecular mechanisms underlying cancer has significantly
improved, most of our knowledge focuses on protein-coding genes that make up a fraction of …

Long non-coding RNAs: potential new biomarkers for predicting tumor invasion and metastasis

C Jiang, X Li, H Zhao, H Liu - Molecular cancer, 2016 - Springer
Long non-coding RNAs (lncRNAs) play important roles in malignant neoplasia. Indeed,
many hallmarks of cancer define that the malignant phenotype of tumor cells are controlled …

Long noncoding RNAs in cancer cells

DH Bach, SK Lee - Cancer letters, 2018 - Elsevier
Long noncoding RNA (lncRNA) has recently been investigated as key modulators that
regulate many biological processes in human cancers via diverse mechanisms. LncRNAs …

[HTML][HTML] The evolution of long noncoding RNA acceptance in prostate cancer initiation, progression, and its clinical utility in disease management

VR Ramnarine, M Kobelev, EA Gibb, M Nouri, D Lin… - European urology, 2019 - Elsevier
Context It is increasingly evident that non–protein-coding regions of the genome can give
rise to transcripts that form functional layers of the cancer genome. One of most abundant …