Abstract The Rho GTPases—RHOA, RAC1 and CDC42—are small GTP binding proteins
that regulate basic biological processes such as cell locomotion, cell division and …

Studies utilizing electron microscopy and live fluorescence microscopy have significantly
enhanced our understanding of the molecular mechanisms that regulate junctional …

Collective cell migration is the coordinated movement of multiple cells connected by
cadherin-based adherens junctions and is essential for physiological and pathological …

Rac (herein referring to the Rac family) and Cdc42 are Rho GTPases that regulate the
formation of lamellipoda and filopodia, and are therefore crucial in processes such as cell …

Background Breast cancer (BC) metastasis is the leading cause of poor prognosis and
therapeutic failure. However, the mechanisms underlying cancer metastasis are far from …

Spermatogenesis is characterized by the seminiferous epithelial cycle, a periodic pattern of
germ cell differentiation with a wave-like progression along the length of seminiferous …

As a member of Rho GAPs family, Rho GTPase-Activating Protein 17 (ARHGAP17)
regulates cytoskeletal recombination, cell polarity, cell proliferation and cell migration …

Invadopodia are protrusive structures that mediate the extracellular matrix (ECM)
degradation required for tumor invasion and metastasis. Rho small GTPases regulate …

The ability to progress and invade through the extracellular matrix is a characteristic shared
by both normal and cancer cells through the formation of structures called invadosomes …

Abstract Rac and Cdc42 are Rho GTPases which regulate the formation of lamellipoda and
filopodia and are therefore crucial in cellular processes such as cell migration. Both Rho …