Reactive oxygen species (ROS) are short-lived and highly reactive molecules. The
generation of ROS in cells exists in equilibrium with a variety of antioxidant defences. At low …

Tumor necrosis factor (TNF) is the prototypic pro-inflammatory cytokine. It is central to host
defense and inflammatory responses but under certain circumstances also triggers cell …

Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's
lymphoma, is clinically heterogeneous: 40% of patients respond well to current therapy and …

Apoptosis induced by TNF-receptor I (TNFR1) is thought to proceed via recruitment of the
adaptor FADD and caspase-8 to the receptor complex. TNFR1 signaling is also known to …

Programmed cell death plays critical roles in a wide variety of physiological processes
during fetal development and in adult tissues. In most cases, physiological cell death occurs …

Death receptors are members of the tumor necrosis factor receptor superfamily
characterized by a cytoplasmic region known as the “death domain” that enables the …

The inactivation of programmed cell death has profound effects not only on the development
but also on the overall integrity of multicellular organisms. Beside developmental …

Tumor necrosis factor-related apoptosis-inducing ligand or Apo 2 ligand (TRAIL/Apo2L) is a
member of the tumor necrosis factor (TNF) family of ligands capable of initiating apoptosis …

Caspase-8 deficiency in certain cells prompts chronic inflammation. One mechanism
suggested to account for this inflammation is enhanced signaling for necrotic cell death …

The hepatocyte is especially vulnerable to injury due to its central role in xenobiotic
metabolism including drugs and alcohol, participation in lipid and fatty acid metabolism, its …