Stress-induced remodelling of the mitral valve: a model for leaflet thickening and superimposed tissue formation in mitral valve disease
BPT Kruithof, L Paardekooper… - Cardiovascular …, 2020 - academic.oup.com
Aims In mitral valve prolapse (MVP), leaflet thickening has recently been suggested to be
due, in addition to a myxomatous degeneration, to the presence of a superimposed tissue …
due, in addition to a myxomatous degeneration, to the presence of a superimposed tissue …
Single-cell analysis reveals the loss of FABP4-positive proliferating valvular endothelial cells relates to functional mitral regurgitation
X Wang, M Fu, W Wang, S Shu, N Zhang, R Zhao… - BMC medicine, 2024 - Springer
Background Functional mitral regurgitation (MR) is a common form of mitral valve
dysfunction that often persists even after surgical intervention, requiring reoperation in some …
dysfunction that often persists even after surgical intervention, requiring reoperation in some …
Tumor necrosis factor alpha and interleukin 1 beta suppress myofibroblast activation via nuclear factor kappa B signaling in 3D-cultured mitral valve interstitial cells
Mitral valve disease is a major cause of cardiovascular morbidity throughout the world. Many
different mitral valve pathologies feature fibrotic remodeling, often accompanied by an …
different mitral valve pathologies feature fibrotic remodeling, often accompanied by an …
Map** the spatial variation of mitral valve elastic properties using air-pulse optical coherence elastography
The mitral valve is a highly heterogeneous tissue composed of two leaflets, anterior and
posterior, whose unique composition and regional differences in material properties are …
posterior, whose unique composition and regional differences in material properties are …
Heart valves' mechanobiology
M Monroe, A Zhu, KJ Grande-Allen - Principles of Heart Valve Engineering, 2019 - Elsevier
Heart valves are subjected to unrelenting mechanical forces as they perform their constant
vital function of precisely opening and closing. Understanding how these mechanics fit in …
vital function of precisely opening and closing. Understanding how these mechanics fit in …
The impact of biological factors, anatomy, and mechanical forces on calcification and fibrosis of cardiac and vascular structures
The cardiovascular system experiences a unique combination of mechanical forces, which
regulate vascular cell signaling in health and disease. Changes in these mechanical signals …
regulate vascular cell signaling in health and disease. Changes in these mechanical signals …
Tissue-engineered models of heart valve development and disease
AS Zhu - 2021 - search.proquest.com
Heart valve diseases are a major cause of cardiovascular morbidity, but their molecular
mechanisms are unclear. Tissue-engineered models of these diseases are necessary to …
mechanisms are unclear. Tissue-engineered models of these diseases are necessary to …
Extracellular Dynamics in Valvular and Vascular Pathophysiology
MN Monroe - 2020 - search.proquest.com
The extracellular matrix varies dramatically in composition and mechanics between tissues,
thereby guiding differential physiological function. Within the cardiovascular system, even …
thereby guiding differential physiological function. Within the cardiovascular system, even …
Christopher B. Sylvester1, 2, Dora Y. Huang1, Elysa Jui1, Kavya L. Singampalli1, 2
The cardiovascular circuit produces and contains unique and powerful physical forces within
the body. These forces not only allow for the circulation of blood but also regulate the health …
the body. These forces not only allow for the circulation of blood but also regulate the health …
[CYTOWANIE][C] Imaging structural and mechanical properties in cardiovascular tissue using optical polarization tractography
L Azinfar - 2022 - University of Missouri--Columbia