In vivo two-photon calcium imaging (2PCI) is a technique used for recording neuronal
activity in the intact brain. It is based on the principle that, when neurons fire action …

Recent progress in fluorescence imaging allows neuroscientists to observe the dynamics of
thousands of individual neurons, identified genetically or by their connectivity, across …

Recent advances in fluorescence imaging permit large-scale recording of neural activity and
dynamics of neurochemical release with unprecedented resolution in behaving animals …

A major open challenge in neuroscience is the ability to measure and perturb neural activity
in vivo from well defined neural sub-populations at cellular resolution anywhere in the brain …

Optogenetics has revolutionized neuroscience in small laboratory animals, but its effect on
animal models more closely related to humans, such as non-human primates (NHPs), has …

The thalamus has long been suspected to have an important role in cognition, yet recent
theories have favored a more corticocentric view. According to this view, the thalamus is an …

Successful application of two-photon imaging with genetic tools in awake macaque
monkeys will enable fundamental advances in our understanding of higher cognitive …

Brain perturbation studies allow detailed causal inferences of behavioral and neural
processes. Because the combination of brain perturbation methods and neural …

Here we describe the development and application of miniature integrated microscopes
(miniscopes) paired with microendoscopes that allow for the visualization and manipulation …

Mesoscopic calcium imaging enables studies of cell-type specific neural activity over large
areas. A growing body of literature suggests that neural activity can be different when …