The daily removal of billions of apoptotic cells in the human body via the process of
efferocytosis is essential for homeostasis. To allow for this continuous efferocytosis, rapid …

Nanotechnology could improve our understanding of the pathophysiology of atherosclerosis
and contribute to the development of novel diagnostic and therapeutic strategies to further …

Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

Macrophages are cells of the innate immune system that regulate the maintenance of tissue
homeostasis, host defense during pathogen infection, and tissue repair in response to tissue …

Liver X receptors α and β (LXRα and LXRβ) are nuclear receptors with pivotal roles in the
transcriptional control of lipid metabolism. Transcriptional activity of LXRs is induced in …

Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver disorders
characterized by abnormal hepatic fat accumulation, inflammation, and hepatocyte …

The liver X receptors (LXRs) are pivotal regulators of lipid homeostasis in mammals. These
transcription factors control the expression of a battery of genes involved in the uptake …

Phagocytic cells of the immune system must constantly survey for, recognize, and efficiently
clear the billions of cellular corpses that arise as a result of development, stress, infection, or …

Small-molecule inhibitors targeting growth factor receptors have failed to show efficacy for
brain cancers, potentially due to their inability to achieve sufficient drug levels in the CNS …

Nuclear receptors are integrators of hormonal and nutritional signals, mediating changes to
metabolic pathways within the body. Given that modulation of lipid and glucose metabolism …