Many naturally occurring substances, traditionally used in popular medicines around the
world, contain the coumarin moiety. Coumarin represents a privileged scaffold for medicinal …

Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Compounds incorporating the chromene scaffold are largely present in natural products and
display a wide variety of biological activities. Their low toxicity combined to the broad …

Coumarin compounds represent an important type of naturally occurring and synthetic
oxygen-containing heterocycles with typical benzopyrone framework. This type of special …

Accumulating evidence shows a relationship between the human MAO-B (hMAO-B) enzyme
and neuropsychiatric/degenerative disorder, personality traits, type II alcoholism, borderline …

This review aims to be a comprehensive, authoritative, critical, and readable review of
general interest to the medicinal chemistry community because it focuses on the …

Monoamine oxidase (MAO) enzyme inhibition is a crucial target for the management of
depression and Alzheimer disease and inhibitors of MAO are the most important drugs for …

Hybrid molecules, furnished by combining two or more pharmacophores is an emerging
concept in the field of medicinal chemistry and drug discovery that has attracted substantial …

The inhibitory action of fifteen benzyloxy ortho/para-substituted chalcones (B1-B15) was
evaluated against human monoamine oxidases (hMAOs). All the molecules inhibited hMAO …

A series of tacrine–coumarin hybrids (8a–t) were designed, synthesized and evaluated as
multifunctional cholinesterase (ChE) inhibitors against Alzheimer's disease (AD). The …