The inflamed brain in schizophrenia: the convergence of genetic and environmental risk factors that lead to uncontrolled neuroinflammation

AL Comer, M Carrier, MÈ Tremblay… - Frontiers in cellular …, 2020 - frontiersin.org
Schizophrenia is a disorder with a heterogeneous etiology involving complex interplay
between genetic and environmental risk factors. The immune system is now known to play …

Effects of inflammation on the kynurenine pathway in schizophrenia—a systematic review

B Pedraz-Petrozzi, O Elyamany, C Rummel… - Journal of …, 2020 - Springer
Background In the last decade, there has been growing evidence that an interaction exists
between inflammation and the kynurenine pathway in schizophrenia. Additionally, many …

Psycho-neuroendocrine-immune interactions in COVID-19: potential impacts on mental health

Í Raony, CS de Figueiredo, P Pandolfo… - Frontiers in …, 2020 - frontiersin.org
Coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2). The impacts of the disease may be beyond the …

Cytokines dysregulation in schizophrenia: a systematic review of psychoneuroimmune relationship

D Rodrigues-Amorim, T Rivera-Baltanas, C Spuch… - Schizophrenia …, 2018 - Elsevier
Introduction: Schizophrenia is a multifactorial psychiatric disease with complex interactions
among the brain and the immune system. A psycho-immune relationship underling …

The effect of acute stress on salivary markers of inflammation: A systematic review and meta-analysis

YZ Szabo, DC Slavish, JE Graham-Engeland - Brain, behavior, and …, 2020 - Elsevier
Background Salivary biomarkers of inflammation are increasingly used in stress research.
This systematic review and meta-analysis provides a quantitative summary of changes in …

The druggable schizophrenia genome: from repurposing opportunities to unexplored drug targets

SG Lago, S Bahn - NPJ genomic medicine, 2022 - nature.com
There have been no new drugs for the treatment of schizophrenia in several decades and
treatment resistance represents a major unmet clinical need. The drugs that exist are based …

Towards novel potential molecular targets for antidepressant and antipsychotic pharmacotherapies

YM Kositsyn, MS de Abreu, TO Kolesnikova… - International Journal of …, 2023 - mdpi.com
Depression and schizophrenia are two highly prevalent and severely debilitating
neuropsychiatric disorders. Both conventional antidepressant and antipsychotic …

Environmental enrichment rescues the effects of early life inflammation on markers of synaptic transmission and plasticity

AC Kentner, A Khoury, EL Queiroz… - Brain, behavior, and …, 2016 - Elsevier
Environmental enrichment (EE) has been successful at rescuing the brain from a variety of
early-life psychogenic stressors. However, its ability to reverse the behavioral and neural …

Convergent lines of evidence supporting involvement of NFKB1 in schizophrenia

J Long, L Tian, A Baranova, H Cao, Y Yao, S Rao… - Psychiatry …, 2022 - Elsevier
Objectives NFKB1 was associated with treatment-refractory schizophrenia (SZ) and
response to antipsychotics; however, the underlying mechanisms through which NFKB1 …

Blood biomarker discovery in drug-free schizophrenia: the contribution of proteomics and multiplex immunoassays

S Sabherwal, JA English, M Föcking… - Expert review of …, 2016 - Taylor & Francis
Introduction: Recent evidence supports an association between systemic abnormalities and
the pathology of psychotic disorders which has led to the search for peripheral blood-based …