Quantification of tumor heterogeneity: from data acquisition to metric generation
Tumors are unique and complex ecosystems, in which heterogeneous cell subpopulations
with variable molecular profiles, aggressiveness, and proliferation potential coexist and …
with variable molecular profiles, aggressiveness, and proliferation potential coexist and …
From complexity to clarity: unravelling tumor heterogeneity through the lens of tumor microenvironment for innovative cancer therapy
Despite the tremendous clinical successes recorded in the landscape of cancer therapy,
tumor heterogeneity remains a formidable challenge to successful cancer treatment. In …
tumor heterogeneity remains a formidable challenge to successful cancer treatment. In …
Immune features are associated with response to neoadjuvant chemo-immunotherapy for muscle-invasive bladder cancer
Neoadjuvant cisplatin-based chemotherapy is standard of care for muscle-invasive bladder
cancer (MIBC). Immune checkpoint inhibition (ICI) alone, and ICI in combination with …
cancer (MIBC). Immune checkpoint inhibition (ICI) alone, and ICI in combination with …
Identification of gastric cancer subtypes based on pathway clustering
Gastric cancer (GC) is highly heterogeneous in the stromal and immune microenvironment,
genome instability (GI), and oncogenic signatures. However, a classification of GC by …
genome instability (GI), and oncogenic signatures. However, a classification of GC by …
Cancer biology, epidemiology, and treatment in the 21st century: current status and future challenges from a biomedical perspective
P Pina-Sanchez, A Chavez-Gonzalez… - Cancer …, 2021 - journals.sagepub.com
Since the second half of the 20th century, our knowledge about the biology of cancer has
made extraordinary progress. Today, we understand cancer at the genomic and epigenomic …
made extraordinary progress. Today, we understand cancer at the genomic and epigenomic …
Multi-region sequencing with spatial information enables accurate heterogeneity estimation and risk stratification in liver cancer
Background Numerous studies have used multi-region sampling approaches to characterize
intra-tumor heterogeneity (ITH) in hepatocellular carcinoma (HCC). However, conventional …
intra-tumor heterogeneity (ITH) in hepatocellular carcinoma (HCC). However, conventional …
Dynamic single-cell RNA-seq analysis reveals distinct tumor program associated with microenvironmental remodeling and drug sensitivity in multiple myeloma
M Chen, Y Wan, X Li, J **ang, X Chen, J Jiang, X Han… - Cell & Bioscience, 2023 - Springer
Background Multiple myeloma (MM) is a hematological malignancy characterized by clonal
proliferation of malignant plasma cells. Despite extensive research, molecular mechanisms …
proliferation of malignant plasma cells. Despite extensive research, molecular mechanisms …
Multifocal organoid capturing of colon cancer reveals pervasive intratumoral heterogenous drug responses
Intratumor heterogeneity (ITH) stands as one of the main difficulties in the treatment of
colorectal cancer (CRC) as it causes the development of resistant clones and leads to …
colorectal cancer (CRC) as it causes the development of resistant clones and leads to …
Spatial transcriptome‐wide profiling of small cell lung cancer reveals intra‐tumoral molecular and subtype heterogeneity
Small cell lung cancer (SCLC) is a highly aggressive malignancy characterized by rapid
growth and early metastasis and is susceptible to treatment resistance and recurrence …
growth and early metastasis and is susceptible to treatment resistance and recurrence …
The effects of clonal heterogeneity on cancer immunosurveillance
Intratumor heterogeneity (ITH) is associated with tumor progression in several clinical and
experimental settings and contributes to therapeutic resistance. Its relation to cancer …
experimental settings and contributes to therapeutic resistance. Its relation to cancer …