This international guideline proposes improving clozapine package inserts worldwide by
using ancestry-based dosing and titration. Adverse drug reaction (ADR) databases suggest …

Objective The lack of resources and coordination to face the coronavirus epidemic raises
concerns for the health of patients with mental disorders in a country where we still have …

Abstract Treatment-resistant schizophrenia (TRS) will affect about one in three patients with
schizophrenia. Clozapine is the only treatment approved for TRS, and patients should be …

With the ongoing coronavirus disease 2019 (COVID-19) pandemic, psychiatrists find
themselves in the clinical situation of being asked by patients, family members and patient …

Abstract Using Richardson and Davidson's model and the sciences of pharmacokinetics and
clinical pharmacopsychology, this article reviewed the:(1) poor life expectancy associated …

Background With the rapid, global spread of severe acute respiratory syndrome coronavirus
2, hospitals have become inundated with patients suffering from coronavirus disease 2019 …

Objective Clozapine is the most effective medication for treatment‐refractory schizophrenia,
but it is associated with severe cardiac adverse events including myocarditis and …

Background: Available in-vitro and animal studies indicate that inflammation impacts
cytochromes P450 (CYP) activity via multiple and complex transcriptional and post …

Objective Clozapine is substantially underutilized in most countries and clinician factors
including lack of knowledge and concerns about adverse drug effects (ADEs) contribute …

Background The immune system appears to be dysregulated in schizophrenia (SZ). The
potential prognostic or diagnostic value of neutrophil-to-lymphocyte ratio (NLR), an …