Advances in organ-on-a-chip engineering
Predicting the effects of drugs before human clinical trials is at the heart of drug screening
and discovery processes. The cost of drug discovery is steadily increasing owing to the …
and discovery processes. The cost of drug discovery is steadily increasing owing to the …
Decellularized extracellular matrix: New promising and challenging biomaterials for regenerative medicine
Extracellular matrix is rich in biomolecules including structural proteins,
glycosaminoglycans, and small molecules that are important for the maintenance and repair …
glycosaminoglycans, and small molecules that are important for the maintenance and repair …
[HTML][HTML] Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development
The first microfluidic microphysiological systems (MPS) entered the academic scene more
than 15 years ago and were considered an enabling technology to human in vitro (patho) …
than 15 years ago and were considered an enabling technology to human in vitro (patho) …
A perfused human blood–brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport
NR Wevers, DG Kasi, T Gray, KJ Wilschut… - Fluids and Barriers of …, 2018 - Springer
Background Receptor-mediated transcytosis is one of the major routes for drug delivery of
large molecules into the brain. The aim of this study was to develop a novel model of the …
large molecules into the brain. The aim of this study was to develop a novel model of the …
Standardizing designed and emergent quantitative features in microphysiological systems
DM Nahon, R Moerkens, H Aydogmus… - Nature biomedical …, 2024 - nature.com
Microphysiological systems (MPSs) are cellular models that replicate aspects of organ and
tissue functions in vitro. In contrast with conventional cell cultures, MPSs often provide …
tissue functions in vitro. In contrast with conventional cell cultures, MPSs often provide …
Perfused 3D angiogenic sprouting in a high-throughput in vitro platform
Angiogenic sprouting, the growth of new blood vessels from pre-existing vessels, is
orchestrated by cues from within the cellular microenvironment, such as biochemical …
orchestrated by cues from within the cellular microenvironment, such as biochemical …
Mechanical stimulation: a crucial element of organ-on-chip models
CL Thompson, S Fu, HK Heywood… - … in bioengineering and …, 2020 - frontiersin.org
Organ-on-chip (OOC) systems recapitulate key biological processes and responses in vitro
exhibited by cells, tissues, and organs in vivo. Accordingly, these models of both health and …
exhibited by cells, tissues, and organs in vivo. Accordingly, these models of both health and …
Advances in predictive in vitro models of drug-induced nephrotoxicity
In vitro screens for nephrotoxicity are currently poorly predictive of toxicity in humans.
Although the functional proteins that are expressed by nephron tubules and mediate drug …
Although the functional proteins that are expressed by nephron tubules and mediate drug …
Organ-on-a-chip engineering: Toward bridging the gap between lab and industry
Organ-on-a-chip (OOC) is a very ambitious emerging technology with a high potential to
revolutionize many medical and industrial sectors, particularly in preclinical-to-clinical …
revolutionize many medical and industrial sectors, particularly in preclinical-to-clinical …
High throughput transepithelial electrical resistance (TEER) measurements on perfused membrane-free epithelia
A Nicolas, F Schavemaker, K Kosim, D Kurek… - Lab on a Chip, 2021 - pubs.rsc.org
Assessment of epithelial barrier function is critically important for studying healthy and
diseased biological models. Here we introduce an instrument that measures transepithelial …
diseased biological models. Here we introduce an instrument that measures transepithelial …