The heterogeneity of mesenchymal stem cells: an important issue to be addressed in cell therapy

J Li, Z Wu, L Zhao, Y Liu, Y Su, X Gong, F Liu… - Stem cell research & …, 2023‏ - Springer
With the continuous improvement of human technology, the medical field has gradually
moved from molecular therapy to cellular therapy. As a safe and effective therapeutic tool …

Applications of mesenchymal stem cells in skin regeneration and rejuvenation

H Jo, S Brito, BM Kwak, S Park, MG Lee… - International journal of …, 2021‏ - mdpi.com
Mesenchymal stem cells (MSCs) are multipotent stem cells derived from adult stem cells.
Primary MSCs can be obtained from diverse sources, including bone marrow, adipose …

[HTML][HTML] The immunomodulatory functions of mesenchymal stromal/stem cells mediated via paracrine activity

Y Zhou, Y Yamamoto, Z **ao, T Ochiya - Journal of clinical medicine, 2019‏ - mdpi.com
Mesenchymal stromal/stem cells (MSCs) exist in almost all tissues, possessing the potential
to differentiate into specialized cell types and exert immunomodulatory functions. Thus, they …

Heterogeneity of mesenchymal stem cells in cartilage regeneration: from characterization to application

K Zha, X Li, Z Yang, G Tian, Z Sun, X Sui… - NPJ Regenerative …, 2021‏ - nature.com
Articular cartilage is susceptible to damage but hard to self-repair due to its avascular
nature. Traditional treatment methods are not able to produce satisfactory effects …

[HTML][HTML] Mesenchymal stem cells in regenerative medicine: focus on articular cartilage and intervertebral disc regeneration

SM Richardson, G Kalamegam, PN Pushparaj, C Matta… - Methods, 2016‏ - Elsevier
Musculoskeletal disorders represent a major cause of disability and morbidity globally and
result in enormous costs for health and social care systems. Development of cell-based …

Umbilical cord-derived mesenchymal stem cells: their advantages and potential clinical utility

T Nagamura-Inoue, H He - World journal of stem cells, 2014‏ - pmc.ncbi.nlm.nih.gov
Human umbilical cord (UC) is a promising source of mesenchymal stem cells (MSCs). Apart
from their prominent advantages, such as a painless collection procedure and faster self …

Umbilical cord as prospective source for mesenchymal stem cell‐based therapy

I Arutyunyan, A Elchaninov, A Makarov… - Stem cells …, 2016‏ - Wiley Online Library
The paper presents current evidence on the properties of human umbilical cord‐derived
mesenchymal stem cells, including origin, proliferative potential, plasticity, stability of …

Concise review: Wharton's jelly: the rich, but enigmatic, source of mesenchymal stromal cells

JE Davies, JT Walker, A Keating - Stem cells translational …, 2017‏ - academic.oup.com
The umbilical cord has become an increasingly used source of mesenchymal stromal cells
for preclinical and, more recently, clinical studies. Despite the increased activity, several …

Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord

HS Wang, SC Hung, ST Peng, CC Huang, HM Wei… - Stem …, 2004‏ - academic.oup.com
The Wharton's jelly of the umbilical cord contains mucoid connective tissue and fibroblast‐
like cells. Using flow cytometric analysis, we found that mesenchymal cells isolated from the …

[HTML][HTML] Mesenchymal stem cells from the Wharton's jelly of the human umbilical cord: biological properties and therapeutic potential

L Marino, MA Castaldi, R Rosamilio, E Ragni… - Int J stem …, 2019‏ - synapse.koreamed.org
Wharton's jelly mesenchymal stem cells (WJ-MSCs) are a class of stem cells with high
differentiative potential, an immuno-privileged status and easy access for collection, which …