Microbiome and human health: current understanding, engineering, and enabling technologies
The human microbiome is composed of a collection of dynamic microbial communities that
inhabit various anatomical locations in the body. Accordingly, the coevolution of the …
inhabit various anatomical locations in the body. Accordingly, the coevolution of the …
[HTML][HTML] Rethinking healthy eating in light of the gut microbiome
Given the worldwide epidemic of diet-related chronic diseases, evidence-based dietary
recommendations are fundamentally important for health promotion. Despite the importance …
recommendations are fundamentally important for health promotion. Despite the importance …
Versatility of bacterial outer membrane vesicles in regulating intestinal homeostasis
X Wang, S Lin, L Wang, Z Cao, M Zhang, Y Zhang… - Science …, 2023 - science.org
Outer membrane vesicles (OMVs) play vital roles in bacterial communication both
intraspecifically and interspecifically. However, extracellular mechanisms of gut microbiota …
intraspecifically and interspecifically. However, extracellular mechanisms of gut microbiota …
Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes
It is unclear how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
leads to the strong but ineffective inflammatory response that characterizes severe …
leads to the strong but ineffective inflammatory response that characterizes severe …
Probiotic‐inspired nanomedicine restores intestinal homeostasis in colitis by regulating redox balance, immune responses, and the Gut Microbiome
Microbiota‐based therapeutics offer innovative strategies to treat inflammatory bowel
diseases (IBDs). However, the poor clinical outcome so far and the limited flexibility of the …
diseases (IBDs). However, the poor clinical outcome so far and the limited flexibility of the …
Reverse metabolomics for the discovery of chemical structures from humans
Determining the structure and phenotypic context of molecules detected in untargeted
metabolomics experiments remains challenging. Here we present reverse metabolomics as …
metabolomics experiments remains challenging. Here we present reverse metabolomics as …
[HTML][HTML] Pathobionts in inflammatory bowel disease: origins, underlying mechanisms, and implications for clinical care
The gut microbiota plays a significant role in the pathogenesis of both forms of inflammatory
bowel disease (IBD), namely Crohn's disease (CD) and ulcerative colitis (UC). While …
bowel disease (IBD), namely Crohn's disease (CD) and ulcerative colitis (UC). While …
[HTML][HTML] Microbiome-based interventions to modulate gut ecology and the immune system
The gut microbiome lies at the intersection between the environment and the host, with the
ability to modify host responses to disease-relevant exposures and stimuli. This is evident in …
ability to modify host responses to disease-relevant exposures and stimuli. This is evident in …
[HTML][HTML] Butyrate's role in human health and the current progress towards its clinical application to treat gastrointestinal disease
K Hodgkinson, F El Abbar, P Dobranowski… - Clinical Nutrition, 2023 - Elsevier
Butyrate is a key energy source for colonocytes and is produced by the gut microbiota
through fermentation of dietary fiber. Butyrate is a histone deacetylase inhibitor and also …
through fermentation of dietary fiber. Butyrate is a histone deacetylase inhibitor and also …
Scientific novelty beyond the experiment
Practical experiments drive important scientific discoveries in biology, but theory‐based
research studies also contribute novel—sometimes paradigm‐changing—findings. Here, we …
research studies also contribute novel—sometimes paradigm‐changing—findings. Here, we …