The pervasiveness of RNA synthesis in eukaryotes is largely the result of RNA polymerase II
(Pol II)-mediated transcription, and termination of its activity is necessary to partition the …

Initiation of RNA synthesis from DNA templates by RNA polymerase (RNAP) is a multi-step
process, in which initial recognition of promoter DNA by RNAP triggers a series of …

Epidemics of drug-resistant bacteria emerge worldwide, even as resistant strains frequently
have reduced fitness compared to their drug-susceptible counterparts. Data from model …

Transcription-coupled DNA repair (TCR) is presumed to be a minor sub-pathway of
nucleotide excision repair (NER) in bacteria. Global genomic repair is thought to perform the …

In bacteria, transcription and translation are coupled processes in which the movement of
RNA polymerase (RNAP)–synthesizing messenger RNA (mRNA) is coordinated with the …

The global regulatory nucleotide ppGpp (" magic spot") regulates transcription from a large
subset of Escherichia coli promoters, illustrating how small molecules can control gene …

Sequence-specific pausing by RNA polymerase (RNAP) during transcription plays crucial
and diverse roles in gene expression. In bacteria, RNA structures are thought to fold within …

Escherichia coli RNA polymerase (RNAP) is the most studied bacterial RNAP and has been
used as the model RNAP for screening and evaluating potential RNAP-targeting antibiotics …

Using single-molecule fluorescence resonance energy transfer, we have defined bacterial
RNA polymerase (RNAP) clamp conformation at each step in transcription initiation and …

Synthetic genetic systems share resources with the host, including machinery for
transcription and translation. Phage RNA polymerases (RNAP s) decouple transcription from …