A research agenda for ageing in China in the 21st century: Focusing on basic and translational research, long-term care, policy and social networks
One of the key issues facing public healthcare is the global trend of an increasingly ageing
society which continues to present policy makers and caregivers with formidable healthcare …
society which continues to present policy makers and caregivers with formidable healthcare …
Deep generative molecular design reshapes drug discovery
Recent advances and accomplishments of artificial intelligence (AI) and deep generative
models have established their usefulness in medicinal applications, especially in drug …
models have established their usefulness in medicinal applications, especially in drug …
Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow
A reduced removal of dysfunctional mitochondria is common to aging and age-related
neurodegenerative pathologies such as Alzheimer's disease (AD). Strategies for treating …
neurodegenerative pathologies such as Alzheimer's disease (AD). Strategies for treating …
Mitophagy in Alzheimer's disease: Molecular defects and therapeutic approaches
Mitochondrial dysfunctions are central players in Alzheimer's disease (AD). In addition,
impairments in mitophagy, the process of selective mitochondrial degradation by autophagy …
impairments in mitophagy, the process of selective mitochondrial degradation by autophagy …
The autophagy–NAD axis in longevity and disease
Autophagy is an intracellular degradation pathway that recycles subcellular components to
maintain metabolic homeostasis. NAD is an essential metabolite that participates in energy …
maintain metabolic homeostasis. NAD is an essential metabolite that participates in energy …
Mitophagy pathways in health and disease
SA Killackey, DJ Philpott, SE Girardin - Journal of Cell Biology, 2020 - rupress.org
Mitophagy is an evolutionarily conserved process involving the autophagic targeting and
clearance of mitochondria destined for removal. Recent insights into the complex nature of …
clearance of mitochondria destined for removal. Recent insights into the complex nature of …
PharmKG: a dedicated knowledge graph benchmark for bomedical data mining
Biomedical knowledge graphs (KGs), which can help with the understanding of complex
biological systems and pathologies, have begun to play a critical role in medical practice …
biological systems and pathologies, have begun to play a critical role in medical practice …
Defective autophagy and mitophagy in aging and Alzheimer's disease
M Tran, PH Reddy - Frontiers in neuroscience, 2021 - frontiersin.org
Aging is the time-dependent process that all living organisms go through characterized by
declining physiological function due to alterations in metabolic and molecular pathways …
declining physiological function due to alterations in metabolic and molecular pathways …
The mitochondrial response to DNA damage
Z Rong, P Tu, P Xu, Y Sun, F Yu, N Tu… - Frontiers in Cell and …, 2021 - frontiersin.org
Mitochondria are double membrane organelles in eukaryotic cells that provide energy by
generating adenosine triphosphate (ATP) through oxidative phosphorylation. They are …
generating adenosine triphosphate (ATP) through oxidative phosphorylation. They are …
[HTML][HTML] Restoring the infected powerhouse: Mitochondrial quality control in sepsis
FML Chavez, LP Gartzke, FE Van Beuningen, SE Wink… - Redox biology, 2023 - Elsevier
Sepsis is a dysregulated host response to an infection, characterized by organ failure. The
pathophysiology is complex and incompletely understood, but mitochondria appear to play a …
pathophysiology is complex and incompletely understood, but mitochondria appear to play a …