Sedentary behavior and physical inactivity are among the leading modifiable risk factors
worldwide for cardiovascular disease and all-cause mortality. The promotion of physical …

Mitochondria are critical organelles responsible for regulating the metabolic status of
skeletal muscle. These organelles exhibit remarkable plasticity by adapting their volume …

Prolonged skeletal muscle inactivity (eg limb immobilization, bed rest, mechanical
ventilation, spinal cord injury, etc.) results in muscle atrophy that manifests into a decreased …

Skeletal muscle, which accounts for approximately 40% of total body weight, is one of the
most dynamic and plastic tissues in the human body and plays a vital role in movement …

Key points The maintenance of optimal mitochondrial content and function is critical for
muscle health. Mitochondrial dynamics play key roles in mitochondrial quality control; …

Skeletal muscle atrophy is the consequence of protein degradation exceeding protein
synthesis. This arises for a multitude of reasons including the unloading of muscle during …

Research investigators have shown a growing interest in investigating alterations underlying
skeletal muscle wasting in patients with cancer. However, skeletal muscle dysfunctions …

Synaptic mitochondria are particularly vulnerable to physiological insults, and defects in
synaptic mitochondria are linked to early pathophysiology of Alzheimer's disease (AD) …

It is well established that mitochondria play a critical role in the metabolic and physiological
adaptation of skeletal muscle to enhanced contractile activity. Several redox-sensitive …

Beside inherited muscle diseases many catabolic conditions such as insulin resistance,
malnutrition, cancer growth, aging, infections, chronic inflammatory status, inactivity, obesity …