[HTML][HTML] Cyclin-dependent kinases in DNA damage response
The cyclin-dependent kinase (CDK) family plays a critical role in a variety of signaling
pathways that regulate transcription and cell-cycle progression. Recently, the role of CDKs …
pathways that regulate transcription and cell-cycle progression. Recently, the role of CDKs …
Contributions of DNA damage to Alzheimer's disease
X Lin, A Kapoor, Y Gu, MJ Chow, J Peng… - International journal of …, 2020 - mdpi.com
Alzheimer's disease (AD) is the most common type of neurodegenerative disease. Its typical
pathology consists of extracellular amyloid-β (Aβ) plaques and intracellular tau …
pathology consists of extracellular amyloid-β (Aβ) plaques and intracellular tau …
53BP1: kee** it under control, even at a distance from DNA damage
E Rass, S Willaume, P Bertrand - Genes, 2022 - mdpi.com
Double-strand breaks (DSBs) are toxic lesions that can be generated by exposure to
genotoxic agents or during physiological processes, such as during V (D) J recombination …
genotoxic agents or during physiological processes, such as during V (D) J recombination …
Lamin B1 sequesters 53BP1 to control its recruitment to DNA damage
L Etourneaud, A Moussa, E Rass, D Genet… - Science …, 2021 - science.org
Double-strand breaks (DSBs) are harmful lesions and a major cause of genome instability.
Studies have suggested a link between the nuclear envelope and the DNA damage …
Studies have suggested a link between the nuclear envelope and the DNA damage …
CDK5–cyclin B1 regulates mitotic fidelity
CDK1 has been known to be the sole cyclin-dependent kinase (CDK) partner of cyclin B1 to
drive mitotic progression. Here we demonstrate that CDK5 is active during mitosis and is …
drive mitotic progression. Here we demonstrate that CDK5 is active during mitosis and is …
CDK5: an oncogene or an anti-oncogene: location location location
Recent studies have uncovered various physiological functions of CDK5 in many
nonneuronal tissues. Upregulation of CDK5 and/or its activator p35 in neurons promotes …
nonneuronal tissues. Upregulation of CDK5 and/or its activator p35 in neurons promotes …
Curcumin/L‐OHP co‐loaded HAP for cGAS‐STING pathway activation to enhance the natural immune response in colorectal cancer
Y **ao, G Guo, H Wang, B Peng, Y Lin… - Bioengineering & …, 2024 - Wiley Online Library
Insufficient immune cell infiltration into the tumor microenvironment (TME) greatly
compromises the clinical application of immune‐checkpoint inhibitors (ICIs)‐based …
compromises the clinical application of immune‐checkpoint inhibitors (ICIs)‐based …
TIPRL1 and its ATM-dependent phosphorylation promote radiotherapy resistance in head and neck cancer
C Cokelaere, R Dok, EE Cortesi, P Zhao, A Sablina… - Cellular Oncology, 2024 - Springer
Purpose TIPRL1 (target of rapamycin signaling pathway regulator-like 1) is a known
interactor and inhibitor of protein phosphatases PP2A, PP4 and PP6–all pleiotropic …
interactor and inhibitor of protein phosphatases PP2A, PP4 and PP6–all pleiotropic …
[HTML][HTML] Functional roles of protein phosphatase 4 in multiple aspects of cellular physiology: a friend and a foe
J Park, DH Lee - BMB reports, 2020 - ncbi.nlm.nih.gov
Abstract Protein phosphatase 4 (PP4), one of serine/threonine phosphatases, is involved in
many critical cellular pathways, including DNA damage response (DNA repair, cell cycle …
many critical cellular pathways, including DNA damage response (DNA repair, cell cycle …
Improved immunotherapy for gastric cancer by nanocomposites with capability of triggering Dual-Damage of Nuclear/Mitochondrial DNA and cGAS/STING-Mediated …
W Guo, Z Chen, Z Li, H Huang, Y Ren, B Zhao… - Chemical Engineering …, 2022 - Elsevier
Immune checkpoint inhibitors-based cancer immunotherapy is yielding great clinical benefit,
but its efficacy is limited in gastric cancer (GC) by the lack of T-cell infiltration in the tumor …
but its efficacy is limited in gastric cancer (GC) by the lack of T-cell infiltration in the tumor …