Distilling biologically meaningful information from cancer genome sequencing data requires
comprehensive identification of somatic alterations using rigorous computational methods …

Metastatic cancer remains an almost inevitably lethal disease,–. A better understanding of
disease progression and response to therapies therefore remains of utmost importance …

In cancer, complex genome rearrangements and other structural alterations, including the
amplification of oncogenes on circular extrachromosomal DNA (ecDNA) elements, drive the …

Focal copy-number amplification is an oncogenic event. Although recent studies have
revealed the complex structure,–and the evolutionary trajectories of oncogene amplicons …

APOBEC mutational signatures SBS2 and SBS13 are common in many human cancer
types. However, there is an incomplete understanding of its stimulus, when it occurs in the …

Translesion DNA synthesis (TLS) facilitates replication over damaged or difficult-to-replicate
templates by employing specialized DNA polymerases. We investigate the effect on …

Human lung cancer is a constellation of tumors with various histological and molecular
properties. To build a preclinical platform that covers this broad disease spectrum, we …

Cancers of unknown primary (CUP) origin account for∼ 3% of all cancer diagnoses,
whereby the tumor tissue of origin (TOO) cannot be determined. Using a uniformly …

Understanding how microbial pathogens adapt to treatments, humans and clinical
environments is key to infer mechanisms of virulence, transmission and drug resistance …

Small cell lung carcinoma (SCLC) is a highly aggressive malignancy that is typically
associated with tobacco exposure and inactivation of RB1 and TP53 genes. Here, we …