Natural products as anticancer agents: current status and future perspectives

A Naeem, P Hu, M Yang, J Zhang, Y Liu, W Zhu… - Molecules, 2022 - mdpi.com
Natural products have been an invaluable and useful source of anticancer agents over the
years. Several compounds have been synthesized from natural products by modifying their …

Anticancer plants: A review of the active phytochemicals, applications in animal models, and regulatory aspects

T Khan, M Ali, A Khan, P Nisar, SA Jan, S Afridi… - Biomolecules, 2019 - mdpi.com
The rising burden of cancer worldwide calls for an alternative treatment solution. Herbal
medicine provides a very feasible alternative to western medicine against cancer. This …

In silico molecular docking studies and MM/GBSA analysis of coumarin-carbonodithioate hybrid derivatives divulge the anticancer potential against breast cancer

SV Pattar, SA Adhoni, CM Kamanavalli… - Beni-Suef University …, 2020 - Springer
Background There are many biomarkers associated with breast cancer. Higher expression
of PIK3CA (Phosphoinositide 3-kinase Cα), in its upregulated form, is associated with Hr+ …

Phenolic compounds: A good choice against chronic degenerative diseases

ML Luna-Guevara, JJ Luna-Guevara… - Studies in natural …, 2018 - Elsevier
Phenolic compounds are a group of metabolites derived from the secondary pathways of
plants. Polyphenols comprise flavonoids, phenolic acids, tannins, lignans, and coumarins …

Scopoletin: A review of its source, biosynthesis, methods of extraction, and pharmacological activities

LD Antika, AN Tasfiyati, H Hikmat… - … für Naturforschung C, 2022 - degruyter.com
Scopoletin, also known as 6-methoxy-7 hydroxycoumarin, is one of the naturally occurring
coumarin commonly found in many edible plants and plays an important role in human …

Coumarins as versatile therapeutic phytomolecules: A systematic review

MK Hussain, S Khatoon, MF Khan, MS Akhtar… - Phytomedicine, 2024 - Elsevier
Background Coumarins, abundantly distributed in a plethora of biologically active
compounds, serve as a fundamental motif in numerous natural products, drugs, and …

Artemisia scoparia: Traditional uses, active constituents and pharmacological effects

J Ding, L Wang, C He, J Zhao, L Si, H Huang - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Artemisia scoparia Waldst. et Kit (A. scoparia), is
an important medicinal plant mainly distributed in China, Korea, Japan, Pakistan, India …

An overview of the pharmacological activities of scopoletin against different chronic diseases

D Parama, S Girisa, E Khatoon, A Kumar… - Pharmacological …, 2022 - Elsevier
Chronic diseases are considered a major public health concern worldwide, and most of
these diseases like cancer, cardiovascular, metabolic, and neurological disorders occur due …

Reversing T-cell exhaustion in immunotherapy: a review on current approaches and limitations

Y Tabana, TC Moon, A Siraki, S Elahi… - Expert opinion on …, 2021 - Taylor & Francis
Introduction: T cell functions are altered during chronic viral infections and tumor
development. This is mainly manifested by significant changes in T cells' epigenetic and …

Exploring the anticancer potential and mechanisms of action of natural coumarins and isocoumarins

M Aqib, S Khatoon, M Ali, S Sajid, MA Assiri… - European Journal of …, 2024 - Elsevier
Natural coumarins and isocoumarins show significant therapeutic potential against cancer in
preclinical studies by targeting multiple pathways and processes. These compounds …