Organs-on-chips: into the next decade
LA Low, C Mummery, BR Berridge, CP Austin… - Nature Reviews Drug …, 2021 - nature.com
Abstract Organs-on-chips (OoCs), also known as microphysiological systems or 'tissue
chips'(the terms are synonymous), have attracted substantial interest in recent years owing …
chips'(the terms are synonymous), have attracted substantial interest in recent years owing …
Brain organoids: advances, applications and challenges
Brain organoids are self-assembled three-dimensional aggregates generated from
pluripotent stem cells with cell types and cytoarchitectures that resemble the embryonic …
pluripotent stem cells with cell types and cytoarchitectures that resemble the embryonic …
Shell microelectrode arrays (MEAs) for brain organoids
Brain organoids are important models for mimicking some three-dimensional (3D)
cytoarchitectural and functional aspects of the brain. Multielectrode arrays (MEAs) that …
cytoarchitectural and functional aspects of the brain. Multielectrode arrays (MEAs) that …
Induction of myelinating oligodendrocytes in human cortical spheroids
Cerebral organoids provide an accessible system for investigations of cellular composition,
interactions, and organization but have lacked oligodendrocytes, the myelinating glia of the …
interactions, and organization but have lacked oligodendrocytes, the myelinating glia of the …
Synaptic dysfunction in neurodegenerative and neurodevelopmental diseases: an overview of induced pluripotent stem-cell-based disease models
E Taoufik, G Kouroupi, O Zygogianni… - Open …, 2018 - royalsocietypublishing.org
Synaptic dysfunction in CNS disorders is the outcome of perturbations in physiological
synapse structure and function, and can be either the cause or the consequence in specific …
synapse structure and function, and can be either the cause or the consequence in specific …
A flexible 3-dimensional microelectrode array for in vitro brain models
Three-dimensional (3D) in vitro models have become increasingly popular as systems to
study cell–cell and cell–ECM interactions dependent on the spatial, mechanical, and …
study cell–cell and cell–ECM interactions dependent on the spatial, mechanical, and …
An FDA/CDER perspective on nonclinical testing strategies: Classical toxicology approaches and new approach methodologies (NAMs)
AM Avila, I Bebenek, JA Bonzo, T Bourcier… - Regulatory Toxicology …, 2020 - Elsevier
Nonclinical testing of human pharmaceuticals is conducted to assess the safety of
compounds to be studied in human clinical trials and for marketing of new drugs. Although …
compounds to be studied in human clinical trials and for marketing of new drugs. Although …
Modeling HIV-1 neuropathogenesis using three-dimensional human brain organoids (hBORGs) with HIV-1 infected microglia
HIV-1 associated neurocognitive disorder (HAND) is characterized by neuroinflammation
and glial activation that, together with the release of viral proteins, trigger a pathogenic …
and glial activation that, together with the release of viral proteins, trigger a pathogenic …
[HTML][HTML] Recommendation on test readiness criteria for new approach methods (NAM) in toxicology: exemplified for developmental neurotoxicity (DNT)
A Bal-Price, HT Hogberg, KM Crofton, M Daneshian… - Altex, 2018 - ncbi.nlm.nih.gov
Multiple non-animal-based test methods have never been formally validated. In order to use
such new approach methods (NAMs) in a regulatory context, criteria to define their …
such new approach methods (NAMs) in a regulatory context, criteria to define their …
Gene–environment interactions in developmental neurotoxicity: a case study of synergy between chlorpyrifos and CHD8 knockout in human brainspheres
S Modafferi, X Zhong, A Kleensang… - Environmental …, 2021 - ehp.niehs.nih.gov
Background: Autism spectrum disorder (ASD) is a major public health concern caused by
complex genetic and environmental components. Mechanisms of gene–environment (G× E) …
complex genetic and environmental components. Mechanisms of gene–environment (G× E) …