Repurposing of kinase inhibitors for treatment of COVID-19
The outbreak of COVID-19, the pandemic disease caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has spurred an intense search for treatments by the …
syndrome coronavirus 2 (SARS-CoV-2), has spurred an intense search for treatments by the …
[HTML][HTML] Anticancer alkaloids from trees: Development into drugs
T Isah - Pharmacognosy reviews, 2016 - ncbi.nlm.nih.gov
Trees have made an enormous phytochemical contribution in anticancer drugs'
development more than any other life form. The contributions include alkaloids that are …
development more than any other life form. The contributions include alkaloids that are …
Inhibiting eukaryotic transcription. Which compound to choose? How to evaluate its activity? Which compound to choose? How to evaluate its activity?
O Bensaude - Transcription, 2011 - Taylor & Francis
This review deals first with general questions: how to evaluate transcription inhibition,
describe changes in nuclear structure due to transcription inhibition, report on genes that are …
describe changes in nuclear structure due to transcription inhibition, report on genes that are …
Phosphoproteome profiling uncovers a key role for CDKs in TNF signaling
Tumor necrosis factor (TNF) is one of the few cytokines successfully targeted by therapies
against inflammatory diseases. However, blocking this well studied and pleiotropic ligand …
against inflammatory diseases. However, blocking this well studied and pleiotropic ligand …
Perspective of cyclin-dependent kinase 9 (CDK9) as a drug target
V Krystof, S Baumli, R Furst - Current pharmaceutical design, 2012 - ingentaconnect.com
Deregulation of cyclin-dependent kinases (CDKs) has been associated with many cancer
types and has evoked an interest in chemical inhibitors with possible therapeutic benefit …
types and has evoked an interest in chemical inhibitors with possible therapeutic benefit …
Acacetin exerts antioxidant potential against atherosclerosis through Nrf2 pathway in apoE−/− Mice
Y Wu, F Song, Y Li, J Li, Y Cui, Y Hong… - Journal of cellular …, 2021 - Wiley Online Library
Oxidative stress has a considerable influence on endothelial cell dysfunction and
atherosclerosis. Acacetin, an anti‐inflammatory and antiarrhythmic, is frequently used in the …
atherosclerosis. Acacetin, an anti‐inflammatory and antiarrhythmic, is frequently used in the …
[HTML][HTML] Drug repurposing of cyclin-dependent kinase inhibitors for neutrophilic acute respiratory distress syndrome and psoriasis
Background Neutrophilic inflammation, characterized by dysregulated neutrophil activation,
triggers a variety of inflammatory responses such as chemotactic infiltration, oxidative bursts …
triggers a variety of inflammatory responses such as chemotactic infiltration, oxidative bursts …
Flavopiridol Protects against Fungal Keratitis due to Aspergillus fumigatus by Alleviating Inflammation through the Promotion of Autophagy
L Gu, C Li, X Peng, H Lin, Y Niu, H Zheng… - ACS Infectious …, 2022 - ACS Publications
Fungal keratitis is a serious infectious keratopathy related to fungal virulence and excessive
inflammatory responses. Autophagy exhibits a potent ability to resolve inflammation during …
inflammatory responses. Autophagy exhibits a potent ability to resolve inflammation during …
Rohitukine, a chromone alkaloid and a precursor of flavopiridol, is produced by endophytic fungi isolated from Dysoxylum binectariferum Hook. f and Amoora rohituka …
Rohitukine, a chromone alkaloid, has gained considerable international attention in recent
years because of its novel semi-synthetic derivative, flavopiridol and P-276-00. Both these …
years because of its novel semi-synthetic derivative, flavopiridol and P-276-00. Both these …
Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer
X Wang, C Yu, C Wang, Y Ma, T Wang, Y Li… - European Journal of …, 2019 - Elsevier
A series of novel, highly potent, selective CDK9 inhibitors with cancer stem cells (CSCs)
inhibition activity were designed and synthesized for non-small-cell lung cancer (NSCLC) …
inhibition activity were designed and synthesized for non-small-cell lung cancer (NSCLC) …