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The end of gating? An introduction to automated analysis of high dimensional cytometry data
Ever since its invention half a century ago, flow cytometry has been a major tool for single‐
cell analysis, fueling advances in our understanding of a variety of complex cellular systems …
cell analysis, fueling advances in our understanding of a variety of complex cellular systems …
Automated optimized parameters for T-distributed stochastic neighbor embedding improve visualization and analysis of large datasets
AC Belkina, CO Ciccolella, R Anno, R Halpert… - Nature …, 2019 - nature.com
Accurate and comprehensive extraction of information from high-dimensional single cell
datasets necessitates faithful visualizations to assess biological populations. A state-of-the …
datasets necessitates faithful visualizations to assess biological populations. A state-of-the …
CyTOF workflow: differential discovery in high-throughput high-dimensional cytometry datasets
High-dimensional mass and flow cytometry (HDCyto) experiments have become a method
of choice for high-throughput interrogation and characterization of cell populations. Here, we …
of choice for high-throughput interrogation and characterization of cell populations. Here, we …
Characterization of T-cell immune responses in clinical trials of the candidate RTS, S malaria vaccine
P Moris, E Jongert, RG van der Most - Human vaccines & …, 2018 - Taylor & Francis
The candidate malaria vaccine RTS, S has demonstrated 45.7% efficacy over 18 months
against all clinical disease in a phase-III field study of African children. RTS, S targets the …
against all clinical disease in a phase-III field study of African children. RTS, S targets the …
Single cell analysis of Crohn's disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties
Abstract Background Intestinal stem cells (ISCs) play indispensable roles in the
maintenance of homeostasis, and also in the regeneration of the damaged intestinal …
maintenance of homeostasis, and also in the regeneration of the damaged intestinal …
IL-10 normalizes aberrant amygdala GABA transmission and reverses anxiety-like behavior and dependence-induced escalation of alcohol intake
Alcohol elicits a neuroimmune response in the brain contributing to the development and
maintenance of alcohol use disorder (AUD). While pro-inflammatory mediators initiate and …
maintenance of alcohol use disorder (AUD). While pro-inflammatory mediators initiate and …
CytoML for cross‐platform cytometry data sharing
CytoML is an R/Bioconductor package that enables cross‐platform import, export, and
sharing of gated cytometry data. It currently supports Cytobank, FlowJo, Diva, and R …
sharing of gated cytometry data. It currently supports Cytobank, FlowJo, Diva, and R …
Clozapine-induced agranulocytosis: evidence for an immune-mediated mechanism from a patient-specific in-vitro approach
F Regen, I Herzog, E Hahn, C Ruehl, N Le Bret… - Toxicology and applied …, 2017 - Elsevier
Use of the atypical antipsychotic clozapine (CZP) is compromised by the risk of potentially
fatal agranulocytosis/granulocytopenia (CIAG). To address this, we have established a …
fatal agranulocytosis/granulocytopenia (CIAG). To address this, we have established a …
From bivariate to multivariate analysis of cytometric data: overview of computational methods and their application in vaccination studies
Flow and mass cytometry are used to quantify the expression of multiple extracellular or
intracellular molecules on single cells, allowing the phenotypic and functional …
intracellular molecules on single cells, allowing the phenotypic and functional …
Structural analysis based on unsupervised learning: Search for a characteristic low-dimensional space by local structures in atomistic simulations
Owing to the advances in computational techniques and the increase in computational
power, atomistic simulations of materials can simulate large systems with higher accuracy …
power, atomistic simulations of materials can simulate large systems with higher accuracy …