Eph receptor Tyr kinases and their membrane-tethered ligands, the ephrins, elicit short-
distance cell–cell signalling and thus regulate many developmental processes at the …

Eph receptors are the largest family of receptor tyrosine kinases and mediate a myriad of
essential processes in humans from embryonic development to adult tissue homeostasis …

The Eph receptors are the largest of the RTK families. Like other RTKs, they transduce
signals from the cell exterior to the interior through ligand-induced activation of their kinase …

Critical roles for EPH receptor (EPH)–ephrin signalling in a range of chronic and
regenerative diseases are increasingly being recognized. In particular, the complex roles of …

The development, homeostasis, and regeneration of complex organ systems require
extensive cell–cell communication to ensure that different cells proliferate, migrate …

Eph receptors, the largest subfamily of receptor tyrosine kinases, are linked with proliferative
disease, such as cancer, as a result of their deregulated expression or mutation. Unlike …

Ephrins are cell-surface tethered guidance cues that bind to Eph receptor tyrosine kinases in
trans on opposing cells. In the develo** nervous system, the Eph–ephrin signaling system …

The visual system is beautifully crafted to transmit information of the external world to visual
processing and cognitive centers in the brain. For visual information to be relayed to the …

Astrocytes are critical participants in synapse development and function, but their role in
synaptic plasticity is unclear. Eph receptors and their ephrin ligands have been suggested to …

Eph receptor tyrosine kinases and their ephrin ligands regulate cell navigation during
normal and oncogenic development. Signaling of Ephs is initiated in a multistep process …