Heme is an essential molecule expressed ubiquitously all through our tissues. Heme plays
major functions in cellular physiology and metabolism as the prosthetic group of diverse …

The interactions between chemokine receptors and their ligands may affect susceptibility to
infectious diseases as well as their clinical manifestations. These interactions mediate both …

Hemolytic diseases, such as sickle cell anemia and thalassemia, are characterized by
enhanced release of hemoglobin and heme into the circulation, heme-iron loading of …

BACKGROUND: Most alloantigens on transfused red blood cells (RBCs) are weakly
immunogenic, with only a 2 to 6 percent overall immunization rate even in patients receiving …

Sickle cell anemia (HbSS) is characterized by hypermetabolism, chronic inflammation, and
increased oxidative stress, but the relationship between these factors is undefined. In this …

Objective—After activation, platelets expose CD40 ligand (CD40L) on their surface, then
subsequently release the inflammatory mediator as a soluble fragment (sCD40L). Because …

An analysis of a prospective cohort of individuals with sickle cell anemia (SCA), enrolled
from birth through adulthood, was conducted to determine if asthma is a risk factor for death …

The clinical approach to thalassemia and hemoglobinopathies, specifically Sickle Cell
Disease (SCD), based on transfusions, iron chelation and bone marrow transplantation has …

BACKGROUND The reason for the difference in susceptibility to red blood cell (RBC)
alloimmunization among patients with sickle cell disease (SCD) is not clearly understood …

Sickle cell disease is a common hemolytic disorder with a broad range of complications,
including vaso-occlusive episodes, acute chest syndrome (ACS), pain, and stroke. Heme …