Diagnostic yield and clinical relevance of expanded genetic testing for cancer patients
Background Genetic testing (GT) for hereditary cancer predisposition is traditionally
performed on selected genes based on established guidelines for each cancer type …
performed on selected genes based on established guidelines for each cancer type …
Uncertainty in healthcare and health decision making: Five methodological and conceptual research recommendations from an interdisciplinary team
Uncertainty is prevalent in various health contexts. It is imperative to understand how health-
related uncertainty can impact individuals' healthcare experiences and health decision …
related uncertainty can impact individuals' healthcare experiences and health decision …
Racial and ethnic disparities in germline genetic testing of patients with young-onset colorectal cancer
P Dharwadkar, G Greenan, EM Stoffel… - Clinical …, 2022 - Elsevier
Background & Aims Up to 20% of younger patients (age< 50 years) diagnosed with
colorectal cancer (CRC) have germline mutations in cancer susceptibility genes. Germline …
colorectal cancer (CRC) have germline mutations in cancer susceptibility genes. Germline …
[HTML][HTML] The impact of communicating uncertain test results in cancer genetic counseling: A systematic mixed studies review
NM Medendorp, PEA van Maarschalkerweerd… - Patient education and …, 2020 - Elsevier
Objective Cancer genetic counseling increasingly involves discussing uncertain test results,
for example because multiple genes are sequenced simultaneously. This review was …
for example because multiple genes are sequenced simultaneously. This review was …
Lynch syndrome limbo: patient understanding of variants of uncertain significance
I Solomon, E Harrington, G Hooker, L Erby… - Journal of Genetic …, 2017 - Springer
Providers and patients encounter challenges related to the management of Variants of
Unknown Significance (VUS). A VUS introduces new counseling dilemmas for the …
Unknown Significance (VUS). A VUS introduces new counseling dilemmas for the …
Clinical management of patients at risk for hereditary breast cancer with variants of uncertain significance in the era of multigene panel testing
Background Rising use of multigene panel testing has led to increased identification of
variants of uncertain significance (VUS). Consensus guidelines state that clinicians should …
variants of uncertain significance (VUS). Consensus guidelines state that clinicians should …
Experiences of patients seeking to participate in variant of uncertain significance reclassification research
S Makhnoon, LT Garrett, W Burke, DJ Bowen… - Journal of community …, 2019 - Springer
Patients' understanding of a genetic variant of unknown clinical significance (VUS) is likely
to influence beliefs about risk implications, consequent medical decisions, and other actions …
to influence beliefs about risk implications, consequent medical decisions, and other actions …
How does re-classification of variants of unknown significance (VUS) impact the management of patients at risk for hereditary breast cancer?
A Kwong, CYS Ho, VY Shin, CH Au, TL Chan… - BMC Medical …, 2022 - Springer
Background The popularity of multigene testing increases the probability of identifying
variants of uncertain significance (VUS). While accurate variant interpretation enables …
variants of uncertain significance (VUS). While accurate variant interpretation enables …
Understanding variants of uncertain significance in the era of multigene panels: through the eyes of the patient
C Reuter, N Chun, M Pariani… - Journal of Genetic …, 2019 - Wiley Online Library
Variants of uncertain significance (VUSs) are often disclosed to patients despite ambiguous
association with disease risk and lack of clinical actionability. It is important to understand …
association with disease risk and lack of clinical actionability. It is important to understand …
Germline variants of uncertain significance, their frequency, and clinico-pathological features in a cohort of Sri Lankan patients with hereditary breast cancer
Abstract Background Next-Generation Sequencing (NGS)-based testing in cancer patients
has led to increased detection of variants of uncertain significance (VUS). VUS are genetic …
has led to increased detection of variants of uncertain significance (VUS). VUS are genetic …