PRL3 as a therapeutic target for novel cancer immunotherapy in multiple cancer types
Phosphatase of Regenerating Liver-3 (PRL3) was discovered in 1998 and was
subsequently found to be correlated with cancer progression and metastasis in 2001 …
subsequently found to be correlated with cancer progression and metastasis in 2001 …
Physiological and oncogenic roles of the PRL phosphatases
The human Phosphatase of Regenerative Liver (PRL) family comprises three members
(PRL‐1,‐2,‐3; gene name PTP 4A1, PTP 4A2, PTP 4A3) that are highly expressed in a …
(PRL‐1,‐2,‐3; gene name PTP 4A1, PTP 4A2, PTP 4A3) that are highly expressed in a …
Phosphatase of regenerating liver‐3 regulates cancer cell metabolism in multiple myeloma
P Abdollahi, EN Vandsemb, S Elsaadi… - The FASEB …, 2021 - Wiley Online Library
Cancer cells often depend on microenvironment signals from molecules such as cytokines
for proliferation and metabolic adaptations. PRL‐3, a cytokine‐induced oncogenic …
for proliferation and metabolic adaptations. PRL‐3, a cytokine‐induced oncogenic …
[HTML][HTML] PRL-3 dephosphorylates p38 MAPK to promote cell survival under stress
Hypoxia within the tumor microenvironment, which leads to excessive ROS and genomic
instability, is one of the hallmarks of cancer, contributing to self-renewal capability …
instability, is one of the hallmarks of cancer, contributing to self-renewal capability …
Endosulfan triggers epithelial-mesenchymal transition via PTP4A3-mediated TGF-β signaling pathway in prostate cancer cells
Y Wang, Y Guo, Y Hu, Y Sun, D Xu - Science of the Total Environment, 2020 - Elsevier
Endosulfan is a persistent organochlorine pesticide that bioaccumulates in human body
through the food chain and thus represents a potential risk to public health. Despite …
through the food chain and thus represents a potential risk to public health. Despite …
Protein tyrosine phosphatase 4A3 (PTP4A3/PRL-3) drives migration and progression of T-cell acute lymphoblastic leukemia in vitro and in vivo
M Wei, MG Haney, DR Rivas, JS Blackburn - Oncogenesis, 2020 - nature.com
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood cancer. There are no
immunotherapies and few molecularly targeted therapeutics available for treatment of this …
immunotherapies and few molecularly targeted therapeutics available for treatment of this …
[HTML][HTML] Protein tyrosine phosphatases in multiple myeloma
Many cell signaling pathways are activated or deactivated by protein tyrosine
phosphorylation and dephosphorylation, catalyzed by protein tyrosine kinases (PTKs) and …
phosphorylation and dephosphorylation, catalyzed by protein tyrosine kinases (PTKs) and …
Cisplatin or Doxorubicin Reduces Cell Viability via the PTPIVA3-JAK2-STAT3 Cascade in Hepatocellular Carcinoma
CJ Li, HW Tsai, YL Chen, CI Wang, YH Lin… - Journal of …, 2023 - Taylor & Francis
Introduction Hepatocellular carcinoma (HCC) accounts for 80% of all liver cancers and is the
2nd leading cause of cancer-related death in Taiwan. Various factors, including rapid cell …
2nd leading cause of cancer-related death in Taiwan. Various factors, including rapid cell …
The effects of endosulfan on cell migration and invasion in prostate cancer cells via the KCNQ1OT1/miR-137-3p/PTP4A3 axis
Y Wang, Y Guo, Y Lu, Y Sun, D Xu - Science of The Total Environment, 2022 - Elsevier
Endosulfan belongs to persistent organic pollutants (POPs), closely related to an increased
risk of prostate cancer (PCa). The existing evidence shows that lncRNAs compete with …
risk of prostate cancer (PCa). The existing evidence shows that lncRNAs compete with …
[HTML][HTML] Protein phosphatases—a touchy enemy in the battle against glioblastomas: a review
A Tomiyama, T Kobayashi, K Mori, K Ichimura - Cancers, 2019 - mdpi.com
Glioblastoma (GBM) is the most common malignant tumor arising from brain parenchyma.
Although many efforts have been made to develop therapies for GBM, the prognosis still …
Although many efforts have been made to develop therapies for GBM, the prognosis still …