Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …

Highlights•The first step in metastasis is invasion of tumor cells into the stroma.•Stromal
collagen is dramatically remodeled during tumor progression.•Tumor cells can invade the …

The AGC kinase subfamily of protein kinases contains 60 members, including PKA, PKG
and PKC. The family comprises some intensely examined protein kinases (such as Akt, S6K …

Rho‐associated kinase (Rho‐kinase/ROCK/ROK) is an effector of the small GTPase Rho
and belongs to the AGC family of kinases. Rho‐kinase has pleiotropic functions including …

The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …

Tumor cells exhibit two different modes of individual cell movement. Mesenchymal-type
movement is characterized by an elongated cellular morphology and requires extracellular …

Twenty years ago, Rho-kinase was identified as an important downstream effector of the
small GTP-binding protein, RhoA. Thereafter, a series of studies demonstrated the important …

Rho GTPases contribute to multiple cellular processes that could affect cancer progression,
including cytoskeletal dynamics, cell cycle progression, transcriptional regulation, cell …

Rho-associated coiled-coil containing kinases (ROCK) were originally identified as effectors
of the RhoA small GTPase.–They belong to the AGC family of serine/threonine kinases and …

Blebs are spherical membrane protrusions that are produced by contractions of the
actomyosin cortex. Blebs are often considered to be a hallmark of apoptosis; however, blebs …