Ocular diseases seriously affect patients' vision and life quality, with a global morbidity of
over 43 million blindness. However, efficient drug delivery to treat ocular diseases …

The ability of chitosan (CTS) to promote mucoadhesion, trigger positive/negative surface
interactions, and open tight junctions has inspired researchers to coat lipid-based and …

Topical instillation of eye drops remains the most common and easiest route of ocular drug
administration, representing the treatment of choice for many ocular diseases. Nevertheless …

Chitosan is a cationic natural polysaccharide, which has emerged as an increasingly
interesting biomaterialover the past few years. It constitutes a novel perspective in drug …

Chitosan (CS) is a hemi-synthetic cationic linear polysaccharide produced by the
deacetylation of chitin. CS is non-toxic, highly biocompatible, and biodegradable, and it has …

Topical drug delivery is one of the most challenging aspects of eye therapy. Eye drops are
the most prevalent drug form, especially for widely distributed anterior segment eye …

The human eye being a complex and a very sensitive organ makes the drug delivery task
challenging. An increase in the intra-ocular pressure at the aqueous humour leads to …

Naloxone is an opioid receptor antagonist that can eradicate all pre-indications of the toxicity
and inverse the opioid overdose. However, oral administration of naloxone offers limitations …

The present research work was designed to develop dorzolamide-loaded chitosan-coated
polycaprolactone nanoparticles (DRZ-CS-PCL-NPs) for improved ocular delivery. The …

The present study aimed at the development and evaluation of tacrolimus gellan gum
nanoparticles (TGNPs) for the effective management of dry eye disease (DED) following …