Self-driving laboratories for chemistry and materials science

G Tom, SP Schmid, SG Baird, Y Cao, K Darvish… - Chemical …, 2024 - ACS Publications
Self-driving laboratories (SDLs) promise an accelerated application of the scientific method.
Through the automation of experimental workflows, along with autonomous experimental …

A field guide to flow chemistry for synthetic organic chemists

L Capaldo, Z Wen, T Noël - Chemical science, 2023 - pubs.rsc.org
Flow chemistry has unlocked a world of possibilities for the synthetic community, but the idea
that it is a mysterious “black box” needs to go. In this review, we show that several of the …

ChemCrow: Augmenting large-language models with chemistry tools

AM Bran, S Cox, O Schilter, C Baldassari… - ar** efficient catalysts for syngas-based higher alcohol synthesis (HAS) remains a
formidable research challenge. The chain growth and CO insertion requirements demand …

Self-driving laboratory for polymer electronics

A Vriza, H Chan, J Xu - Chemistry of Materials, 2023 - ACS Publications
Owing to the chemical pluripotency and viscoelastic nature of electronic polymers, polymer
electronics have shown unique advances in many emerging applications such as skin-like …

Rapid planning and analysis of high-throughput experiment arrays for reaction discovery

B Mahjour, R Zhang, Y Shen, A McGrath… - Nature …, 2023 - nature.com
High-throughput experimentation (HTE) is an increasingly important tool in reaction
discovery. While the hardware for running HTE in the chemical laboratory has evolved …

Continuous flow synthesis of pyridinium salts accelerated by multi-objective Bayesian optimization with active learning

JH Dunlap, JG Ethier, AA Putnam-Neeb, S Iyer… - Chemical …, 2023 - pubs.rsc.org
We report a human-in-the-loop implementation of the multi-objective experimental design
via a Bayesian optimization platform (EDBO+) towards the optimization of butylpyridinium …

Autonomous, multiproperty-driven molecular discovery: From predictions to measurements and back

BA Koscher, RB Canty, MA McDonald, KP Greenman… - Science, 2023 - science.org
A closed-loop, autonomous molecular discovery platform driven by integrated machine
learning tools was developed to accelerate the design of molecules with desired properties …