Small molecule metabolites: discovery of biomarkers and therapeutic targets
S Qiu, Y Cai, H Yao, C Lin, Y **e, S Tang… - Signal Transduction and …, 2023 - nature.com
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …
Naturally occurring antioxidant therapy in Alzheimer's disease
AE Collins, TM Saleh, BE Kalisch - Antioxidants, 2022 - mdpi.com
It is estimated that the prevalence rate of Alzheimer's disease (AD) will double by the year
2040. Although currently available treatments help with symptom management, they do not …
2040. Although currently available treatments help with symptom management, they do not …
Natural polyphenolic nanodots for Alzheimer's disease treatment
The abnormal amyloid‐β accumulation is essential and obbligato in Alzheimer's disease
pathogenesis and natural polyphenols exhibit great potential as amyloid aggregation …
pathogenesis and natural polyphenols exhibit great potential as amyloid aggregation …
Functional amyloids from bacterial biofilms–structural properties and interaction partners
Protein aggregation and amyloid formation have historically been linked with various
diseases such as Alzheimer's and Parkinson's disease, but recently functional amyloids …
diseases such as Alzheimer's and Parkinson's disease, but recently functional amyloids …
Self-Assembly of Cysteine into Nanofibrils Precedes Cystine Crystal Formation: Implications for Aggregation Inhibition
The self-association of metabolites into well-ordered assemblies at the nanoscale has
significant biological and medical implications. The thiol-containing amino acid cysteine …
significant biological and medical implications. The thiol-containing amino acid cysteine …
Hypertension and hyperhomocysteinemia as modifiable risk factors for Alzheimer's disease and dementia: New evidence, potential therapeutic strategies, and …
This review summarizes recent evidence on how mid‐life hypertension,
hyperhomocysteinemia (HHcy) and blood pressure variability, as well as late‐life …
hyperhomocysteinemia (HHcy) and blood pressure variability, as well as late‐life …
Glucosylceramide associated with Gaucher Disease forms amyloid-like twisted ribbon fibrils that induce α-synuclein Aggregation
A major risk factor for Gaucher's disease is loss of function mutations in the GBA1 gene that
encodes lysosomal β-glucocerebrosidase, resulting in accumulation of glucosylceramide …
encodes lysosomal β-glucocerebrosidase, resulting in accumulation of glucosylceramide …
The metabolostasis network and the cellular depository of aggregation‐prone metabolites
The vital role of metabolites across all branches of life and their involvement in various
disorders have been investigated for decades. Many metabolites are poorly soluble in water …
disorders have been investigated for decades. Many metabolites are poorly soluble in water …
Toxic metabolites and inborn errors of amino acid metabolism: what one informs about the other
N Lee, D Kim - Metabolites, 2022 - mdpi.com
In inborn errors of metabolism, such as amino acid breakdown disorders, loss of function
mutations in metabolic enzymes within the catabolism pathway lead to an accumulation of …
mutations in metabolic enzymes within the catabolism pathway lead to an accumulation of …
Branched-chain amino acid assembly into amyloid-like fibrils provides a new paradigm for maple syrup urine disease pathology
Inborn error of metabolism disorders (IEMs) are a family of diseases resulting from single-
gene mutations that lead to the accumulation of metabolites that are usually toxic or interfere …
gene mutations that lead to the accumulation of metabolites that are usually toxic or interfere …