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[HTML][HTML] Complex roles of NEIL1 and OGG1: insights gained from murine knockouts and human polymorphic variants
RS Lloyd - Dna, 2022 - mdpi.com
DNA glycosylases promote genomic stability by initiating base excision repair (BER) in both
the nuclear and mitochondrial genomes. Several of these enzymes have overlap** …
the nuclear and mitochondrial genomes. Several of these enzymes have overlap** …
Polymorphic variant Asp239Tyr of human DNA glycosylase NTHL1 is inactive for removal of a variety of oxidatively-induced DNA base lesions from genomic DNA
Base excision repair is the major pathway for the repair of oxidatively-induced DNA damage,
with DNA glycosylases removing modified bases in the first step. Human NTHL1 is specific …
with DNA glycosylases removing modified bases in the first step. Human NTHL1 is specific …
DNA Sequence Modulates the Efficiency of NEIL1-Catalyzed Excision of the Aflatoxin B1-Induced Formamidopyrimidine Guanine Adduct
Dietary exposure to aflatoxins is a significant risk factor in the development of hepatocellular
carcinomas. Following bioactivation by microsomal P450s, the reaction of aflatoxin B1 …
carcinomas. Following bioactivation by microsomal P450s, the reaction of aflatoxin B1 …
Inhibition of Human APE1 and MTH1 DNA Repair Proteins by Dextran-Coated γ-Fe2O3 Ultrasmall Superparamagnetic Iron Oxide Nanoparticles
Aim: To quantitatively evaluate the inhibition of human DNA repair proteins APE1 and MTH1
by dextran-coated γ-Fe2O3 ultrasmall superparamagnetic iron oxide nanoparticles …
by dextran-coated γ-Fe2O3 ultrasmall superparamagnetic iron oxide nanoparticles …
Inhibition by tetrahydroquinoline sulfonamide derivatives of the activity of human 8-oxoguanine DNA glycosylase (OGG1) for several products of oxidatively induced …
DNA glycosylases involved in the first step of the DNA base excision repair pathway are
promising targets in cancer therapy. There is evidence that reduction of their activities may …
promising targets in cancer therapy. There is evidence that reduction of their activities may …