Pain is a multidimensional experience with sensory-discriminative, affective-motivational,
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …

Chronic, pathological pain remains a global health problem and a challenge to basic and
clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been …

The sensory, associative and limbic neocortical structures play a critical role in sha**
incoming noxious inputs to generate variable pain perceptions. Technological advances in …

Sound—including music and noise—can relieve pain in humans, but the underlying neural
mechanisms remain unknown. We discovered that analgesic effects of sound depended on …

In humans, tissue injury and depression can both cause pain hypersensitivity, but whether
this involves distinct circuits remains unknown. Here, we identify two discrete glutamatergic …

Over the past 20 years, clinical and preclinical studies point to the anterior cingulate cortex
(ACC) as a site of interest for several neurological and psychiatric conditions. The ACC …

Chronic pain patients frequently develop and suffer from mental comorbidities such as
depressive mood, impaired cognition, and other significant constraints of daily life, which …

The anterior cingulate cortex (ACC) plays an important role in pain modulation, and pain-
related emotional disorders. In the ACC, two major forms of long-term potentiation (LTP) …

The primary motor cortex (M1) is involved in the control of voluntary movements and is
extensively mapped in this capacity. Although the M1 is implicated in modulation of pain, the …

The somatosensory system processes diverse types of information including mechanical,
thermal, and chemical signals. It has an essential role in sensory perception and body …