The Keap1/Nrf2/ARE system is a central defensive mechanism against oxidative stress
which plays a key role in the pathogenesis and progression of many diseases. Nrf2 is a …

Osteoporosis (OP), characterized by continuous bone loss and increased fracture risk, has
posed a challenge to patients and society. Long-term administration of current …

Thiram, a widely used organic pesticide in agriculture, exhibits both bactericidal and
insecticidal effects. However, prolonged exposure to thiram has been linked to bone …

Infection and loosening of implants after joint replacement are the complications that have
troubled patients and doctors for a long time. To prevent such complications, we selected …

Tibial dyschondroplasia (TD) occurs in chickens and other fast-growing birds, affecting their
cartilage growth and leading to reduced meat quality in broilers. Morinda officinalis …

Tetramethyl thiuram disulfide (thiram) is an important dithiocarbamate bactericide; it has
been widely used for the control of various diseases in fruits, vegetables, seeds and food …

Tetramethyl thiuram disulfide (thiram) is a dithiocarbamate pesticide used for crop protection
and storage. But, it's widespread utilization is associated with deleterious growth plate …

Multifunctionality has becoming essential for bone tissue engineering materials, such as
drug release. In this study, icariin (ICA)-incorporated poly (glycolide-co …

Thiram, an agricultural insecticide, has been demonstrated to induce tibial dyschondroplasia
(TD) in avian species. Circular RNA (circRNAs), a novel class of functional biological …

Highlights•Thiram caused tibial dyschondroplasia (TD) in boiler chickens.•TD caused growth
retardation and tibial growth plate (GP) abnormalities.•Baicalin reduced GP abnormalities …