Recent advances in technology are expected to increase our current understanding of
neuroscience. Nanotechnology and nanomaterials can alter and control neural functionality …

Systemic forms of amyloidosis affecting the heart are mostly light-chain (AL) and
transthyretin (ATTR) amyloidoses. The latter is caused by deposition of misfolded …

Despite the strong evidence linking the transactive response DNA-binding protein 43 (TDP-
43) aggregation to the pathogenesis of frontotemporal lobar degeneration with TDP-43 …

The acquisition of strong chiroptical activity has revolutionized the field of plasmonics,
granting access to novel light–matter interactions and revitalizing research on both the …

Abnormal accumulation of aggregated α-synuclein (α-Syn) is seen in a variety of
neurodegenerative diseases, including Parkinson's disease (PD), multiple system atrophy …

Synthetic peptides that self-assemble into cross-β fibrils are versatile building blocks for
engineered biomaterials due to their modularity and biocompatibility, but their structural and …

The lack of detailed insight into the structure of aggregates formed by the huntingtin protein
(HTT) has hampered the efforts to develop therapeutics and diagnostics targeting pathology …

In patients with amyotrophic lateral sclerosis (ALS), disease symptoms and pathology
typically spread in a predictable spatiotemporal pattern beginning at a focal site of onset and …

Atomically precise metal nanoclusters (MNCs) represent a fascinating class of ultrasmall
nanoparticles with molecule-like properties, bridging conventional metal–ligand complexes …

Highlights•Human amyloids can undergo both functional and pathogenic aggregation,
making any such classifications non-trivial.•Polar residues are more prevalent in functional …