Background Chronic and/or extreme stress in early life, often referred to as early adversity,
childhood trauma, or early life stress, has been associated with a wide range of adverse …

In response to rapidly growing rates of comorbidity among psychiatric disorders, clinical
scientists have become interested in identifying transdiagnostic processes that can help …

Discovering the processes through which early adverse experiences affect children's
nervous-system development, health, and behavior is critically important for develo** …

A growing body of research has examined the impact of childhood adversity on neural
structure and function. Advances in our understanding of the neurodevelopmental …

Over the past decade, a growing area of research has focused on adverse childhood
experiences (ACEs) and their impacts on neural and developmental outcomes. Work in the …

Vulnerability to emotional disorders including depression derives from interactions between
genes and environment, especially during sensitive developmental periods. Adverse early …

Under typical conditions, medial prefrontal cortex (mPFC) connections with the amygdala
are immature during childhood and become adult-like during adolescence. Rodent models …

In this article, we provide a fresh perspective on the developmental origins of neuroticism—a
dimension of temperament marked by elevated stress reactivity resulting in the frequent …

Adversity early in life is common and is a major risk factor for the onset of psychopathology.
Delineating the neurodevelopmental pathways by which early adversity affects mental …

Childhood poverty has pervasive negative physical and psychological health sequelae in
adulthood. Exposure to chronic stressors may be one underlying mechanism for childhood …