Targeting ROS in cancer: rationale and strategies

C Glorieux, S Liu, D Trachootham… - Nature Reviews Drug …, 2024 - nature.com
Reactive oxygen species (ROS) in biological systems are transient but essential molecules
that are generated and eliminated by a complex set of delicately balanced molecular …

ROS production and signalling in chloroplasts: cornerstones and evolving concepts

CH Foyer, G Hanke - The Plant Journal, 2022 - Wiley Online Library
Reactive oxygen species (ROS) such as singlet oxygen, superoxide (O2●−) and hydrogen
peroxide (H2O2) are the markers of living cells. Oxygenic photosynthesis produces ROS in …

A brief guideline for studies of phase-separated biomolecular condensates

Y Gao, X Li, P Li, Y Lin - Nature Chemical Biology, 2022 - nature.com
Cells are exquisitely compartmentalized to achieve precise spatiotemporal regulation of
myriad processes and pathways. Phase separation offers one way to achieve territorial …

Transcription regulation by biomolecular condensates

G Pei, H Lyons, P Li, BR Sabari - Nature Reviews Molecular Cell …, 2024 - nature.com
Biomolecular condensates regulate transcription by dynamically compartmentalizing the
transcription machinery. Classic models of transcription regulation focus on the recruitment …

Intrinsically disordered regions are poised to act as sensors of cellular chemistry

D Moses, GM Ginell, AS Holehouse… - Trends in biochemical …, 2023 - cell.com
Intrinsically disordered proteins and protein regions (IDRs) are abundant in eukaryotic
proteomes and play a wide variety of essential roles. Instead of folding into a stable …

The cytosolic thiol peroxidase PRXIIB is an intracellular sensor for H2O2 that regulates plant immunity through a redox relay

G Bi, M Hu, L Fu, X Zhang, J Zuo, J Li, J Yang, JM Zhou - Nature plants, 2022 - nature.com
Rapid production of H2O2 is a hallmark of plant responses to diverse pathogens and plays a
crucial role in signalling downstream of various receptors that perceive immunogenic …

Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis

B Wang, H Zhang, J Huai, F Peng, J Wu, R Lin… - Nature Chemical …, 2022 - nature.com
Osmotic stress imposed by drought and high salinity inhibits plant growth and crop yield.
However, our current knowledge on the mechanism by which plants sense osmotic stress is …

Post-translational modifications in liquid-liquid phase separation: a comprehensive review

J Li, M Zhang, W Ma, B Yang, H Lu, F Zhou… - Molecular …, 2022 - Springer
Liquid-liquid phase separation (LLPS) has received significant attention in recent biological
studies. It refers to a phenomenon that biomolecule exceeds the solubility, condensates and …

Cysteine thiol-based post-translational modification: what do we know about transcription factors?

H Zhou, J Huang, P Willems, F Van Breusegem… - Trends in Plant …, 2023 - cell.com
Reactive electrophilic species are ubiquitous in plant cells, where they contribute to specific
redox-regulated signaling events. Redox signaling is known to modulate gene expression …

Reactive oxygen species: multidimensional regulators of plant adaptation to abiotic stress and development

P Wang, WC Liu, C Han, S Wang… - Journal of Integrative …, 2024 - Wiley Online Library
Reactive oxygen species (ROS) are produced as undesirable by‐products of metabolism in
various cellular compartments, especially in response to unfavorable environmental …