Ischemic heart disease (IHD) is the leading cause of disability and mortality worldwide.
Reactive oxygen species (ROS) have been shown to play key roles in the progression of …

Red blood cells (RBCs) constitute a unique drug delivery system as a biologic or hybrid
carrier capable of greatly enhancing pharmacokinetics, altering pharmacodynamics (for …

Acute respiratory distress syndrome (ARDS) is characterized by the severe inflammation
and destruction of the lung air–blood barrier, leading to irreversible and substantial …

Thrombomodulin (TM) is an integral component of a multimolecular system, localized
primarily to the vascular endothelium, that integrates crucial biological processes and …

Red blood cell (RBC) hitchhiking is a method of drug delivery that can increase drug
concentration in target organs by orders of magnitude. In RBC hitchhiking, drug-loaded …

Drug delivery research pursues many types of carriers including proteins and other
macromolecules, natural and synthetic polymeric structures, nanocarriers of diverse …

Drug targeting to inflammatory brain pathologies such as stroke and traumatic brain injury
remains an elusive goal. Using a mouse model of acute brain inflammation induced by local …

Endothelial cells play critical roles in circulatory homeostasis and are also the gateway to
the major organs of the body. Dysfunction, injury, and gene expression profiles of these cells …

The bloodstream is the main transporting pathway for drug delivery systems (DDS) from the
site of administration to the intended site of action. In many cases, components of the …

Endothelial cell dysfunction occurs in a variety of acute and chronic pulmonary diseases
including pulmonary hypertension, viral and bacterial pneumonia, bronchopulmonary …