In the last decade, single-cell RNA sequencing routinely performed on large numbers of
single cells has greatly advanced our understanding of the underlying heterogeneity of …

Most research aiming at understanding the molecular foundations of life and disease has
focused on a limited set of increasingly well-known proteins while the biological functions of …

Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular
composition under physiological and pathophysiological conditions. The emergence of …

The paired measurement of RNA and surface proteins in single cells with cellular indexing
of transcriptomes and epitopes by sequencing (CITE-seq) is a promising approach to …

Single-cell proteomics can reveal cellular phenotypic heterogeneity and cell-specific
functional networks underlying biological processes. Here, we present a streamlined …

Biological systems are composed of heterogeneous populations of cells that
intercommunicate to form a functional living tissue. Biological function varies greatly across …

Single-cell (SC) analysis provides unique insight into individual cell dynamics and cell-to-
cell heterogeneity. Here, we utilize trapped ion mobility separation coupled with dual …

Large-scale single-cell analyses are of fundamental importance in order to capture
biological heterogeneity within complex cell systems, but have largely been limited to RNA …

Global quantification of protein abundances in single cells could provide direct information
on cellular phenotypes and complement transcriptomics measurements. However, single …

Raman spectroscopy has made significant progress in biosensing and clinical research.
Here, we describe how surface-enhanced Raman spectroscopy (SERS) assisted with …