Abstract Exportin 1 (XPO1), also known as chromosome region maintenance protein 1,
plays a crucial role in maintaining cellular homeostasis via the regulated export of a range of …

Fluorine is characterized by high electronegativity and small atomic size, which provide this
molecule with the unique property of augmenting the potency, selectivity, metabolic stability …

Background Relapsed or refractory diffuse large B-cell lymphoma (DLBCL) is an aggressive
cancer with a median overall survival of less than 6 months. We aimed to assess the …

Compared with traditional therapies, targeted therapy has merits in selectivity, efficacy, and
tolerability. Small molecule inhibitors are one of the primary targeted therapies for cancer …

NPM1 is the most frequently mutated gene in cytogenetically normal acute myeloid leukemia
(AML). In AML cells, NPM1 mutations result in abnormal cytoplasmic localization of the …

Liposarcomas are rare malignant tumors of adipocytic differentiation. The classification of
liposarcomas into four principal subtypes reflects the distinct clinical behavior, treatment …

Central to eukaryotic cell function, transport into and out of the nucleus is largely mediated
by members of the Importin (IMP) superfamily of transporters of α-and β-types. The first …

Purpose Selinexor, a first-in-class, oral, selective exportin 1 (XPO1) inhibitor, induces
apoptosis in cancer cells through nuclear retention of tumor suppressor proteins and the …

The outbreak of the novel coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as a serious public health …

Selinexor is a novel, first-in-class, selective inhibitor of nuclear export compound, which
blocks exportin 1 (XPO1) function, leads to nuclear accumulation of tumor suppressor …