Polymer–drug conjugates have long been a mainstay of the drug delivery field, with several
conjugates successfully translated into clinical practice. The conjugation of therapeutic …

Proof of principles studies by Inoue and coworkers in the late 1960s clearly illustrated the
poorly controlled coupling of CO 2 and epoxides to provide polycarbonates. These early …

Poor water solubility and low bioavailability of active pharmaceutical ingredients (APIs) are
major causes of friction in the pharmaceutical industry and represent a formidable hurdle for …

Carbon dioxide (CO 2) is an abundant, inexpensive, nontoxic, and renewable C1 resource
in organic synthesis. Converting CO 2 into high-value-added fuels or materials has attracted …

Target-site drug delivery systems are gaining interest in the pharmaceutical field due to their
great advantages, such as higher drug dosing capacity and better bioavailability. However …

Carbon dioxide (CO2) is cheap, renewable, abundant, and nontoxic carbon feedstocks in
chemical reactions. In the past two decades, utilization of CO2 in polymer science has …

Although nanomedicines have been pursued for nearly 20 years, fundamental chemical
strategies that seek to optimize both the drug and drug carrier together in a concerted effort …

We report the synthesis of block copolymers of monomethoxylated polyethylene glycol and
poly (glycerol carbonate)(mPEG-b-PGC) via the ring-opening polymerization of benzyl …

Insertion of CO2 into the polyacrylate backbone, forming poly (carbonate) analogues,
provides an environmentally friendly and biocompatible alternative. The synthesis of five …

Breast cancer is among the most prevalent malignancies, accounting for 685,000 deaths
worldwide in 2020, largely due to its high metastatic potential. Depending on the stage and …