Type 1 diabetes
Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and
resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past …
resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past …
The heterogeneous pathogenesis of type 1 diabetes mellitus
J Ilonen, J Lempainen, R Veijola - Nature Reviews Endocrinology, 2019 - nature.com
Type 1 diabetes mellitus (T1DM) results from the destruction of pancreatic β-cells that is
mediated by the immune system. Multiple genetic and environmental factors found in …
mediated by the immune system. Multiple genetic and environmental factors found in …
New frontiers in the treatment of type 1 diabetes
Type 1 diabetes is an autoimmune disease caused by the immune-mediated destruction of
pancreatic β cells that results in lifelong absolute insulin deficiency. For nearly a century …
pancreatic β cells that results in lifelong absolute insulin deficiency. For nearly a century …
T cell-mediated beta cell destruction: autoimmunity and alloimmunity in the context of type 1 diabetes
Type 1 diabetes (T1D) results from destruction of pancreatic beta cells by T cells of the
immune system. Despite improvements in insulin analogs and continuous blood glucose …
immune system. Despite improvements in insulin analogs and continuous blood glucose …
COVID-19 survival associates with the immunoglobulin response to the SARS-CoV-2 spike receptor binding domain
M Secchi, E Bazzigaluppi, C Brigatti… - The Journal of …, 2020 - Am Soc Clin Investig
BACKGROUND Serological assays are of critical importance to investigate correlates of
response and protection in coronavirus disease 2019 (COVID-19), to define previous …
response and protection in coronavirus disease 2019 (COVID-19), to define previous …
Autoantibodies targeting intracellular and extracellular proteins in autoimmunity
Detecting autoantibodies provides foundational information for the diagnosis of most
autoimmune diseases. An important pathophysiological distinction is whether …
autoimmune diseases. An important pathophysiological distinction is whether …
Molecular interactions sha** the tetraspanin web
SJ van Deventer, VME Dunlock… - Biochemical Society …, 2017 - portlandpress.com
To facilitate the myriad of different (signaling) processes that take place at the plasma
membrane, cells depend on a high degree of membrane protein organization. Important …
membrane, cells depend on a high degree of membrane protein organization. Important …
Optogenetic β cell interrogation in vivo reveals a functional hierarchy directing the Ca2+ response to glucose supported by vitamin B6
Coordination of cellular activity through Ca2+ enables β cells to secrete precise quantities of
insulin. To explore how the Ca2+ response is orchestrated in space and time, we implement …
insulin. To explore how the Ca2+ response is orchestrated in space and time, we implement …
Islet autoantibodies
V Lampasona, D Liberati - Current diabetes reports, 2016 - Springer
Islet autoantibodies are the main markers of pancreatic autoimmunity in type 1 diabetes
(T1D). Islet autoantibodies recognize insulin (IAA), glutamic acid decarboxylase (GADA) …
(T1D). Islet autoantibodies recognize insulin (IAA), glutamic acid decarboxylase (GADA) …
Translation of cell therapies to treat autoimmune disorders
Autoimmune diseases are a diverse and complex set of chronic disorders with a substantial
impact on patient quality of life and a significant global healthcare burden. Current …
impact on patient quality of life and a significant global healthcare burden. Current …