Extensive research during the past 2 decades has revealed the mechanism by which
continued oxidative stress can lead to chronic inflammation, which in turn could mediate …

Infection and inflammation are associated with downregulation of hepatic and extrahepatic
cytochrome P450s as well as other drug‐metabolizing enzymes and transporters. We review …

Studies on the increasing number of transporters found in the placental barrier are gaining
momentum, because of their tissue‐specific expression, significance in physiology and …

Background: While establishing efficacy in translational models and humans through
clinically-relevant endpoints for disease is of great interest, assessing the potential toxicity of …

The human placenta fulfills a variety of essential functions during prenatal life. Several ABC
transporters are expressed in the human placenta, where they play a role in the transport of …

Transporters comprise the largest family of membrane proteins in human organism,
including members of solute carrier transporter and ATP-binding cassette transporter …

The liver has a key role in the metabolism (ie, inactivation or activation) of many commonly
used anticancer agents—cytotoxics or new biological agents. Therefore, assessment of liver …

Many intrinsic and extrinsic factors can affect an individual patient's drug exposure and
response. 1 The US Food and Drug Administration (FDA) has published a number of …

Inflammation plays a critical role in host defense, maintaining cellular and tissue integrity
following chemical, physical and biological insults. Inflammation presents in a variety of …