The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …

Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …

Current treatment options for diabetic wounds face challenges due to low efficacy, as well as
potential side effects and the necessity for repetitive treatments. To address these issues, we …

Tumour-Associated Macrophages (TAMs) are one of the pivotal components of the tumour
microenvironment. Their roles in the cancer immunity are complicated, both pro-tumour and …

Background This study aimed to investigate the potential mechanism of paeonol in the
treatment of neuropathic pain. Methods Relevant mechanisms were explored through …

Pain imposes a significant urden on patients, affecting them physically, psychologically, and
economically. Despite numerous studies on the pathogenesis of pain, its clinical …

Myocardial infarction (MI)-induced impaired cardiomyocyte (CM) mitochondrial function and
microenvironmental inflammatory cascades severely accelerate the progression of heart …

Pulmonary arterial hypertension (PAH) is a severe cardiopulmonary vascular disease
characterized by progressive pulmonary artery pressure elevation, increased pulmonary …

Chronic pain is a long-standing unpleasant sensory and emotional feeling that has a
tremendous impact on the physiological functions of the body, manifesting itself as a …

Current evidence suggests that activation of glial and immune cells leads to increased
production of proinflammatory mediators, creating a neuroinflammatory state …