Proteoforms, which arise from post-translational modifications, genetic polymorphisms and
RNA splice variants, play a pivotal role as drivers in biology. Understanding proteoforms is …

Top-down mass spectrometry (MS)-based proteomics is a powerful technology for
comprehensively characterizing proteoforms to decipher post-translational modifications …

Recent innovations in differentiating cardiomyocytes from human induced pluripotent stem
cells (hiPSCs) have unlocked a viable path to creating in vitro cardiac models. Currently …

Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CM) may
provide an important bridge between animal models and the intact human myocardium …

Coupled electromechanical waves define a heart's function in health and diseases. Optical
map** of electrical waves using fluorescent labels offers mechanistic insights into cardiac …

The mechanical function of the myocardium is defined by cardiomyocyte contractility and the
biomechanics of the extracellular matrix (ECM). Understanding this relationship remains an …

While identification-centric (qualitative) top-down proteomics (TDP) has seen rapid progress
in the recent past, the quantification of intact proteoforms within complex proteomes is still …

Truncation mutations in cardiac myosin binding protein C (cMyBP-C) are common causes of
hypertrophic cardiomyopathy (HCM). Heterozygous carriers present with classical HCM …

Human pluripotent stem-cell-derived cardiomyocytes (hPSC-CMs) show immense promise
for patient-specific disease modeling, cardiotoxicity screening, and regenerative therapy …

Bioactive peptides exhibit key roles in a wide variety of complex processes, such as
regulation of body weight, learning, aging, and innate immune response. Next to the …