Lung cancer is the leading cause of cancer-related death across the world. Unlike lung
adenocarcinoma, patients with lung squamous cell carcinoma (LSCC) have not benefitted …

The success of immunotherapy in oncology underscores the vital role of the immune system
in cancer development. Regulatory T cells (Tregs) maintain a fine balance between …

Lipid phosphoinositides are master regulators of almost all aspects of a cell's life and death
and are generated by the tightly regulated activity of phosphoinositide kinases. Although …

Abstract The phosphatidylinositol 3-kinase (PI3K) signalling pathway regulates cell survival,
proliferation, migration, metabolism and other vital cellular life processes. In addition …

Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancers
worldwide. More than half of patients with HNSCC eventually experience disease …

Generating stem-like memory T cells (TSCM) is a potential strategy to improve adoptive
immunotherapy. Elucidating optimal ways to modulate signaling pathways that enrich TSCM …

The PI3K signaling pathway regulates key cellular processes and is one of the most
aberrantly activated pathways in cancer. The class I PI3K catalytic subunits p110γ and …

Regulatory T cells (Tregs) expressing the transcription factor FoxP3 are essential for
maintaining immunological balance and are a significant component of the …

Cancer patients treated with immune checkpoint inhibitors (ICIs) are susceptible to a broad
and variable array of immune‐related adverse events (irAEs). With increasing clinical use of …

The phosphoinositide 3-kinase (PI3K) pathway regulates diverse cellular processes, with
finely tuned PI3Kδ activity being crucial for immune cell development and function. Genetic …