Neonatal development of intestinal neuroimmune interactions
EM Schill, AN Floyd, RD Newberry - Trends in neurosciences, 2022 - cell.com
Interactions between the enteric nervous system (ENS), immune system, and gut microbiota
regulate intestinal homeostasis in adults, but their development and role (s) in early life are …
regulate intestinal homeostasis in adults, but their development and role (s) in early life are …
Endothelin signaling in development
SM Kanai, DE Clouthier - Development, 2023 - journals.biologists.com
Since the discovery of endothelin 1 (EDN1) in 1988, the role of endothelin ligands and their
receptors in the regulation of blood pressure in normal and disease states has been …
receptors in the regulation of blood pressure in normal and disease states has been …
Depletion of muscularis macrophages ameliorates inflammation-driven dysmotility in murine colitis model
Previously, the presence of a blood-myenteric plexus barrier and its disruption was reported
in experimentally induced colitis via a macrophage-dependent process. The aim of this …
in experimentally induced colitis via a macrophage-dependent process. The aim of this …
Reducing underdiagnosis of Hirschsprung-associated enterocolitis: a novel scoring system
RA Lewit, LV Veras, RA Cowles, K Fowler… - Journal of Surgical …, 2021 - Elsevier
Abstract Background Hirschsprung-Associated Enterocolitis (HAEC) is a life-threatening and
difficult to diagnose complication of Hirschsprung Disease (HSCR). The goal of this study …
difficult to diagnose complication of Hirschsprung Disease (HSCR). The goal of this study …
Ednrb −/− mice with hirschsprung disease are missing Gad2-expressing enteric neurons in the ganglionated small intestine
Hirschsprung disease is most often characterized by aganglionosis limited to the distal colon
and rectum, and mice lacking the Endothelin receptor type B (Ednrb) faithfully recapitulate …
and rectum, and mice lacking the Endothelin receptor type B (Ednrb) faithfully recapitulate …
Applications of single-cell sequencing technology to the enteric nervous system
With recent technical advances and diminishing sequencing costs, single-cell sequencing
modalities have become commonplace. These tools permit analysis of RNA expression …
modalities have become commonplace. These tools permit analysis of RNA expression …
Tamoxifen administration alters gastrointestinal motility in mice
S Bhave, WLN Ho, K Cheng, M Omer… - …, 2022 - Wiley Online Library
Background Tamoxifen is widely used for Cre‐estrogen receptor‐mediated genomic
recombination in transgenic mouse models to mark cells for lineage tracing and to study …
recombination in transgenic mouse models to mark cells for lineage tracing and to study …
Abnormal enteric nervous system and motor activity in the ganglionic proximal bowel of Hirschsprung's disease
Hirschsprung's disease (HSCR) is a congenital defect in which the enteric nervous system
(ENS) does not develop in the distal bowel, requiring surgical removal of the portions of …
(ENS) does not develop in the distal bowel, requiring surgical removal of the portions of …
[HTML][HTML] Causes and consequences: development and pathophysiology of Hirschsprung disease
AJ Burns, AM Goldstein - World Journal of Pediatric Surgery, 2024 - pmc.ncbi.nlm.nih.gov
Hirschsprung disease (HSCR) is a congenital enteric neuropathy in which the enteric
nervous system (ENS) fails to develop along variable lengths of the distal gastrointestinal …
nervous system (ENS) fails to develop along variable lengths of the distal gastrointestinal …
[PDF][PDF] Hirschsprung Disease; Insights into Developmental Etiology, Pathophysiology and Postoperative Long-Term Outcomes
ST Abdelrahman, TA Ezzat, MI Saleh, SM Sakr… - Austin J Clin …, 2022 - researchgate.net
Hirschsprung disease, or aganglionic megacolon, is a devastating neurocristopathy
characterized by the absence of the enteric nervous system in the distal bowel, resulting …
characterized by the absence of the enteric nervous system in the distal bowel, resulting …