The tumor microenvironment (TME) is a critical regulator of tumor growth, progression, and
metastasis. Among the innate immune cells recruited to the tumor site, macrophages are the …

Chronic inflammation and immune responses are two core element that characterize the
tumor microenvironment. A large number of immune/inflammatory cells (including tumor …

Tumor microenvironment is a complex system that contains multiple cells and cytokines.
Among the multiple immune cells, macrophage is particularly abundant and plays an …

Therapy resistance is a characteristic of cancer cells that significantly reduces the
effectiveness of drugs. Despite the popularity of cisplatin (CP) as a chemotherapeutic agent …

The stiffness of the extracellular matrix (ECM) plays an important role in regulating the
cellular programming. However, the mechanical characteristics of ECM affecting cell …

Ovarian cancer is the most lethal gynecological malignancy worldwide. Most patients are
diagnosed at late stages because of atypical symptoms and the lack of effective early …

The identification of prognostic and predictive markers is crucial for choosing the most
appropriate management method for ovarian cancer patients. We aimed to assess the …

Abstract Development of novel strategies to overcome chemoresistance is central goal in
ovarian cancer research. Natural history of the cancer development and progression is …

Mitochondria undergo fission and fusion continually for survival through the course of
cellular adaption processes in response to changes in the surrounding environment …

Background. The treatment of platinum‐resistant recurrent ovarian cancer (PROC) is a
clinical challenge and a hot topic. Tumor microenvironment (TME) as a key factor promoting …