Since the discovery of ocular dominance plasticity, neuroscientists have understood that
changes in visual experience during a discrete developmental time, the critical period …

Neuronal networks with strong recurrent connectivity provide the brain with a powerful
means to perform complex computational tasks. However, high-gain excitatory networks are …

To produce consistent sensory perception, neurons must maintain stable representations of
sensory input. However, neurons in many regions exhibit progressive drift across days …

The relationship between the brain and the environment is flexible, forming the foundation
for our ability to learn. Here we review the current state of our understanding of the …

Vision is the sense humans rely on most to navigate the world, make decisions, and perform
complex tasks. Understanding how humans see thus represents one of the most …

The role of postnatal experience in sculpting cortical circuitry, while long appreciated, is
poorly understood at the level of cell types. We explore this in the mouse primary visual …

Motor cortex is important for motor skill learning, particularly the dexterous skills necessary
for our favorite sports and careers. We are especially interested in understanding how …

Astrocytes regulate the formation and function of neuronal synapses via multiple signals;
however, what controls regional and temporal expression of these signals during …

The ability of the adult mammalian brain to compensate for neuronal loss caused by injury or
disease is very limited. Transplantation aims to replace lost neurons, but the extent to which …

The primary visual cortex of higher mammals is organized into two-dimensional maps,
where the preference of cells for stimulus parameters is arranged regularly on the cortical …