The capacity of bone tissue to alter its mass and structure in response to mechanical
demands has long been recognized but the cellular mechanisms involved remained poorly …

Bones are able to withstand functional loads without either breaking or sustaining extensive
damage because they have evolved the capacity to adapt their architecture in relation to …

This second edition of the Bone Mechanics Handbook summarizes the current
understanding of bone mechanics with comprehensive coverage of the histology …

Mechanical stimulation of cultured osteocytic cells attenuates their apoptosis. We report here
that, conversely, reduced mechanical forces in the murine model of unloading by tail …

A wide variety of laboratory apparatuses have been devised for mechanical stimulation of
cell and tissue cultures. This article reviews the functional attributes of several dozen …

A preliminary expression profiling analysis of osteoblasts derived from tibia explants of the
high bone mass LRP5 G171V transgenic mice demonstrated increased expression of …

A model is presented that provides a resolution to a fundamental paradox in bone
physiology, namely, that the strains applied to whole bone (ie, tissue level strains) are much …

Estrogen withdrawal in women leads initially to rapid bone loss caused by increased
numbers or activity of osteoclasts. We previously have noted apoptosis of lacunar osteocytes …

Bones serve several mechanical functions, including acoustic amplification in the middle
ear, shielding vital organs from trauma, and serving as levers for muscles to contract against …

The skeleton's primary mechanical function is to provide rigid levers for muscles to act
against as they hold the body upright in defiance of gravity. Many bones are exposed to …