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G protein-coupled receptor signaling: transducers and effectors
G protein-coupled receptors (GPCRs) are of considerable interest due to their importance in
a wide range of physiological functions and in a large number of Food and Drug …
a wide range of physiological functions and in a large number of Food and Drug …
The role of structural dynamics in GPCR‐mediated signaling
G protein‐coupled receptors (GPCRs) play critical roles in the regulation of human
physiology in response to a wide array of different extracellular stimuli and thus represent …
physiology in response to a wide array of different extracellular stimuli and thus represent …
Common activation mechanism of class A GPCRs
Class A G-protein-coupled receptors (GPCRs) influence virtually every aspect of human
physiology. Understanding receptor activation mechanism is critical for discovering novel …
physiology. Understanding receptor activation mechanism is critical for discovering novel …
Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design
G protein-coupled receptors (GPCRs) are the most common proteins targeted by approved
drugs. A complete mechanistic elucidation of large-scale conformational transitions …
drugs. A complete mechanistic elucidation of large-scale conformational transitions …
[HTML][HTML] How GPCR phosphorylation patterns orchestrate arrestin-mediated signaling
Binding of arrestin to phosphorylated G-protein-coupled receptors (GPCRs) controls many
aspects of cell signaling. The number and arrangement of phosphates may vary …
aspects of cell signaling. The number and arrangement of phosphates may vary …
Structural basis of GPBAR activation and bile acid recognition
The G-protein-coupled bile acid receptor (GPBAR) conveys the cross-membrane signalling
of a vast variety of bile acids and is a signalling hub in the liver–bile acid–microbiota …
of a vast variety of bile acids and is a signalling hub in the liver–bile acid–microbiota …
Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes
Dopamine receptors, including D1-and D2-like receptors, are important therapeutic targets
in a variety of neurological syndromes, as well as cardiovascular and kidney diseases. Here …
in a variety of neurological syndromes, as well as cardiovascular and kidney diseases. Here …
Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection
Y Wei, M Lu, M Mei, H Wang, Z Han, M Chen… - Nature …, 2020 - nature.com
Oxidative stress is a major pathogenic mechanism in Parkinson's disease (PD). As an
important cellular antioxidant, glutathione (GSH) balances the production and incorporation …
important cellular antioxidant, glutathione (GSH) balances the production and incorporation …
Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation
Cellular functions of arrestins are determined in part by the pattern of phosphorylation on the
G protein-coupled receptors (GPCRs) to which arrestins bind. Despite high-resolution …
G protein-coupled receptors (GPCRs) to which arrestins bind. Despite high-resolution …
Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2
QT He, P **ao, SM Huang, YL Jia, ZL Zhu… - Nature …, 2021 - nature.com
Arrestins recognize different receptor phosphorylation patterns and convert this information
to selective arrestin functions to expand the functional diversity of the G protein-coupled …
to selective arrestin functions to expand the functional diversity of the G protein-coupled …